Dyrk1B在宫颈癌组织中表达及其临床意义.docVIP

Dyrk1B在宫颈癌组织中表达及其临床意义 　　[摘要] 目的 探讨DyrklB在宫颈癌组织中的表达及其临床意义。 方法 利用免疫组化检测DyrklB在60例宫颈癌组织、60例宫颈癌癌旁组织和60例正常宫颈组织中的表达，分析DyrklB在宫颈癌组织中的表达状况以及与宫颈癌临床参数的关系。 结果 Dyrk1B 在宫颈癌组织中的表达（60/60，100%）明显高于癌旁组织（26/40，65%）和正常宫颈组织（16/40，40%），三组间比较差异有统计学意义（χ2=88.21，P0.05）。 结论 DyrklB在宫颈癌中高表达，提示其可能参与了肿瘤的发生和发展，并有望成为宫颈癌早期诊断的标志物和治疗的靶基因。 　　[关键词] Mirk/Dyrk1B；宫颈癌；免疫组化 　　[中图分类号] R737.33 [文献标识码] A [文章编号] 1673-9701（2015）28-0001-03 　　Expression and clinical significance of Dyrk1B in cervical carcinoma 　　LIU Minjie1 FANG Laifu2 HU Pingping1 WENG Kena1 BIAN Jia1 MAO Jiayu1 　　1.Department of Obstetrics and Gynecology，Yinzhou People`s Hospital of Ningbo City，Ningbo 315040，China；2.Department of Pathology，Yinzhou People`s Hospital of Ningbo City，Ningbo 315040，China 　　[Abstract] Objective To investigate the expression of DyrklB in cervical cancer and its clinical significance. Methods Immunohistochemical methods were used to detect the expression levels of DryklB in 60 cases cervical carcinoma tissues，60 cases of cervical cancer adjacent tissues and 60 cases normal cervical tissues. DryklB expression in cervical carcinoma and relationship with clinical parameters of cervical carcinoma. Results The expression of Dyrk1B in cervical cancer tissues was significantly higher than that in cervical cancer adjacent tissues and normal cervical tissues，and there was statistical significance between the three groups（χ2=88.21，P0.05）. Conclusion The expression level of Dyrk1b in cervical carcinoma tissues is high，which indicates that it may participate in the occurrence and development of cervical carcinoma ，and it may become a tumor marker for clinical early diagnosis and a new target gene for treatment of cervical carcinoma. 　　[Key words] Mirk/Dyrk1B；Cervical carcinoma；Immunohistoehemical 　　双重特异性酪氨酸磷酸化调节激酶1B（dual-specificity tyrosine-phosphorylation regulated kinase 1B，Dyrk1B；又称Mirk）属Minibrain Dyrk家族成员，是一种苏氨酸/丝氨酸蛋白激酶，该蛋白基因定位在人类19号染色体q12-13.11上，其功能是特异性磷酸化下游的双链酪氨酸[1]，是一种特异性的双链酪氨酸磷酸化激酶[2]，最初是从结肠癌细胞株[3]和人类睾丸组织[4]中分离出来