Gal―3与急性心肌梗死后心功能相关性及瑞舒伐他汀干预作用.docVIP

Gal―3与急性心肌梗死后心功能相关性及瑞舒伐他汀干预作用 　　【摘要】 目的：探讨Gal-3与急性心肌梗死患者心功能的相关性，及瑞舒伐他汀的治疗作用。方法：将60例急性心肌梗死患者随机分为A组、B组，每组各30例，所有患者接受急诊PCI治疗，同时应用阿司匹林、氯吡格雷、β受体阻滞剂、钙离子拮抗剂或血管紧张素转换酶抑制剂/血管紧张素抑制剂、依诺肝素等药物。A组口服瑞舒伐他汀10 mg，qn，B组口服瑞舒伐他汀20 mg，qn。患者入院PCI术前，治疗后1周、4周测定Gal-3、NT-proBNP浓度。入院治疗后24 h、1周、4周测定左室射血分数（LVEF）。结果：（1）治疗后1周两组患者Gal-3水平较PCI术前明显升高（P0.05），NT-proBNP水平较PCI术前明显降低（P0.05），LVEF较入院24 h升高（P0.05），两组比较差异均无统计学意义。（2）治疗后4周两组患者Gal-3、NT-proBNP水平均较治疗后1周明显降低（P0.05），LVEF较治疗后1周明显升高（P0.05），B组变化更明显（P0.05）。相关性分析表明，Gal-3与NT-proBNP呈正相关（r=0.72，P0.05），与LVEF呈负相关（r=-0.761，P0.05）。结论：AMI患者Gal-3水平与心功能变化呈负相关，可以反映AMI患者的心功能情况；长期大剂量口服瑞舒伐他汀可改善心肌梗死后心肌纤维化，改善心功能。 　　【关键词】 Gal-3； 急性心肌梗死； 心功能； 瑞舒伐他汀 　　Effects of Rosuvastatin on Cardic Function and the Relationship between Galectin-3 and Cardic function in Patients with Acute Myocardial Infarction/LI Zhao-xin，ZHAI Zhao-hui，LI Yao-min，et al.//Medical Innovation of China，2014，11（32）：008-011 　　【Abstract】 Objective：To observe the relationship between Galectin-3 and cardic function and the effect of Rosuvastatin on Galectin-3 and cardic function after acute myocardial infarction（AMI）.Method：60 patients with AMI in our hospital were enrolled. They were randomly divided into group A and group B， with 30 cases in each group. All patients were received percutaneous coronary intervention（PCI）.Patients in group A were orally administrated with 10 mg/qn of rosuvastatin， and group B received 20 mg/qn of Rosuvastatin. The levels of Gal-3，NT-proBNP were measured before PCI and after one week，four weeks；LVEF were measured at 24 h， after PCI one week， four weeks.Result：（1）At one week after PCI， the levels of Gal-3 were increased significantly（P0.05）.（2）At four weeks after PCI， compared with one week， the levels of Gal-3 and NT-proBNP were decreased significantly（P0.05），LVEF were decreased significantly（P0.05）.Compared with Group A， the changes of Group B were obviously（P0.05）. The levels of Gal-3 and NT-proBNP in patients with AMI was positively correlated（r=0.72，P0.05）.The levels of Gal