不同剂量瑞舒伐他汀对急性冠脉综合征患者血清炎症因子和颈动脉斑块影响.docVIP

不同剂量瑞舒伐他汀对急性冠脉综合征患者血清炎症因子和颈动脉斑块的影响 　　[摘要] 目的 探讨不同剂量瑞舒伐他汀对急性冠脉综合征（acute coronary syndrome，ACS）患者血清炎症因子和颈动脉斑块的影响。 方法 选择2012年9月～2014年10月在我院心内科住院诊治的ACS患者90例，随机分为瑞舒伐他汀10 mg组和瑞舒伐他汀20 mg组，每组各45例。两组患者分别在ACS常规治疗基础上加用瑞舒伐他汀10 mg和20 mg，疗程12周。观察并对比两组患者治疗前后血脂、血清炎症因子水平和颈动脉斑块的变化情况。结果 治疗后，两组患者血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和基质金属蛋白酶-9（MMP-9）水平均较治疗前明显下降，且瑞舒伐他汀20 mg组下降更明显，差异有统计学意义（P0.05）。两组患者斑块大小、厚度和颈动脉内膜中层厚度（IMT）均较治疗前明显减小，且瑞舒伐他汀20 mg组减少更明显，差异有统计学意义（P0.05）。 结论 瑞舒伐他汀对ACS患者不但具有良好的调脂作用，还具有抗炎作用，减轻斑块内炎症反应，稳定动脉粥样斑块，且20 mg瑞舒伐他汀改善更明显。 　　[关键词] 瑞舒伐他汀；急性冠脉综合征；炎症因子；血脂；颈动脉斑块 　　[中图分类号] R541.4 [文献标识码] A [文章编号] 1673-9701（2015）26-0015-04 　　The influences of different doses of rosuvastatin on serum inflammatory factors and carotid plaque in patients with acute coronary syndrome 　　DONG Zhihua 　　The Second Department of Cardiology，Central Hospital of Liaoyang in Liaoning Province，Liaoyang 111000，China 　　[Abstract] Objective To investigate the influences of different doses of rosuvastatin on serum inflammatory factor and carotid plaque in patients with acute coronary syndrome（ACS）. Methods Ninety patients with ACS were randomly divided into 10 mg rosuvastatin group and 20 mg rosuvastatin group with 45 cases in each group from September 2012 to October 2014. The two groups of patients took 10 mg and 20 mg rosuvastatin on the basis of conventional treatment for 12 weeks. The inflammatory factors，blood lipid and the changes of carotid plaque were observed and compared before and after treatment in both groups. Results After treatment， the levels of tumor necrosis factor α（TNF-α），interleukin 6（IL-6），matrix metalloproteinase 9（MMP-9），carotid plaques size，thickness and intima-media thickness（IMT） decreased more significantly in both groups（P0.05）. Compared with the 10 mg rosuvastatin group，the decreasing levels in 20 mg rosuvastatin group improved more obviously（P0.05）. Conclusion Rosuvastatin can improve blood lipid and plaques inflammation in ACS patients with anti-inflammatory effect. It can make athe