不同激素吸入治疗方式对儿童支气管哮喘疗效评价.docVIP

不同激素吸入治疗方式对儿童支气管哮喘的疗效评价 　　[摘要] 目的 探讨不同激素吸入治疗方式对儿童支气管哮喘的临床疗效。 方法 选择我院收治的支气管哮喘患儿92例，随机分成两组：压力驱动泵吸入治疗组（A组）和储雾罐+压力定量气雾剂吸入治疗组（B组），每组46例。对两组临床疗效进行比较。 结果 治疗期间，两组患儿的临床症状评分均逐渐降低（F = 5.42、6.24， P 0.05），而PEF%和FEV1%均逐渐增高（F = 4.62、5.64，P 0.05）；治疗后同期比较，A组患儿的临床症状评分、PEF%和FEV1%的改善程度均明显优于B组（P 0.05）。A组患儿的治疗依从率明显高于B组（χ2=5.06， P 0.05），而发作次数和发作总天数均明显较B组少（t = 5.73，7.64、P 0.05）。 结论 压力驱动泵吸入较储雾罐+压力定量气雾剂吸入对控制支气管哮喘患儿急性发作效果更好。 　　[关键词] 布地奈德；支气管哮喘；儿童 　　[中图分类号] R725.6 [文献标识码] B [文章编号] 1673-9701（2012）30-0043-02 　　Efficacy of different inhalation regimens for children with bronchial asthma 　　MA Shaokang1 XIAO Wenliang1 LU Yanling2 　　1.The Second Outpatient Services of Shijie Hospital in Guangdong Province， Dongguan 523290， China； 2.Neonatology Department of Dongguan Peoples Hospital in Guangdong Province，Dongguan 523059， China 　　[Abstract] Objective To study the effects of different bud esnide inhahtion regimens for remissive children with bronchial asthma. Methods A total of 92 children with bronchial asthma were divided into two goup： pressure driven pump group（A group） ，spacer and pMDI group（B group）.The effects of two groups were compared. Results The clinical symptoms score of two groups decreased gradually during the treatment（F = 5.42，6.24， P 0.05），and the levels of PEF% and FEV1% increased gradually during the treatment （F = 4.62， 5.64， P 0.05）. The clinical symptoms score and the levels of PEF% and FEV1% of A group were better than that of B group （P 0.05）. The rate of treatment compliance of A group was higher than that of B group （χ2=5.06， P 0.05），and the number and days of episodes were lower than those of B group（t = 5.73， 7.64， P 0.05）. Conclusion Compared with spacer and pMDI，pressure driven pump is more adequate for children with bronchial asthma. 　　[Key words] Bud esnide；Bronchial asthma；Children 　　支气管哮喘是世界范围内最常见的儿童慢性呼吸系统非感染性疾病之一，其患病率逐年上升。目前临床病例调查结果显示，不经过合理治疗的支气管哮喘患儿中约50%成年之后发展为成人哮喘，因此早期正确诊断、规范化治疗对控制儿童支气管哮喘、减少成人哮喘以及哮喘并发症的发生有着重要的临床意义和社会效益[1，2]。雾化吸入布地奈德（糖皮质激素）用于儿童支气管哮喘治疗已得