中性粒细胞明胶酶相关脂质运载蛋白在妊娠糖尿病妇女体内变化及意义.docVIP

中性粒细胞明胶酶相关脂质运载蛋白在妊娠糖尿病妇女体内的变化及意义 　　【摘要】 目的：探讨妊娠糖尿病妇女体内中性粒细胞明胶酶相关脂质运载蛋白（NGAL）的变化及意义。方法：选取2013年1月-2014年12月在本院内分泌科及产科门诊进行常规体检的妊娠中晚期妇女（孕24～28周）60例，按OGTT试验结果分为妊娠糖尿病组及健康孕妇组，每组各30例。检测受试者血NGAL水平并进行比较，了解各指标在两组体内表达的异同。结果：妊娠糖尿病组体内NGAL、hsCRP水平明显高于健康对照组，两组比较差异均有统计学意义（P0.05）。结论：中性粒细胞明胶酶相关脂质运载蛋白在妊娠糖尿病妇女体内水平升高，且与炎症标志物hsCRP关联紧密，有可能成为协助判断妊娠糖尿病疾病发生的一种检测指标。 　　【关键词】 妊娠糖尿病； 中性粒细胞明胶酶相关脂质运载蛋白； 检测指标 　　Changes and Significance for Neutrophil Gelatinase Associated Lipocalin in Women with Gestational Diabetes Mellitus/HE Xiao-jie，CHEN Shun-di， KE Xiao-yan，et al.//Medical Innovation of China，2015，12（34）：057-060 　　【Abstract】 Objective：To explore the changes and significance of neutrophil gelatinase associated lipocalin （NGAL） in women with gestational diabetes. Method：60 pregnant women（24-28 weeks of pregnancy）who visited the endocrine and gynecology clinic in our hospital were recruited from January 2013 to December 2014.According to the OGTT results，they were divided into the gestational diabetic group and the control group， 30 cases in each group.NGAL of two groups were measured and compared. Result：Levels of NGAL and hs-CRP in the gestational diabetic group were higher than the control group，the difference was statistically significant（P0.05） in the two groups.Conclusion：Levels of neutrophil gelatinase associated lipocalin may rise up in the body of gestational diabetic women and associated tightly with inflammatory marker hs-CRP.NGAL may be a helpful detecting index for the judgment of the occurrence of gestational diabetes mellitus. 　　【Key words】 Gestational diabetes mellitus； Neutrophil gelatinase associated lipocalin； Detecting index 　　First-author’s address：People’s Hospital of Maoming，Maoming 525000，China 　　doi：10.3969/j.issn.1674-4985.2015.34.018 　　妊娠糖尿病（Gestational diabetes mellitus，GDM）指患者在妊娠前无糖尿病或糖耐量异常，妊娠期间发生或首次被发现存在的任何程度的糖代谢异常。其确切发病机制尚未清楚，目前认为主要参与因素有遗传、胰岛素抵抗和分泌缺陷、慢性炎性反应等。据报道，该病与孕妇日后出现糖耐量异常、2型糖尿病等具有极强的相关性。此类孕妇在产后6～12周，将有43.1%转归为糖耐量异常，在产后5～16年，将有约17%～63%的孕妇发展为2型糖尿病患者[1-3]。国