二甲双胍联合来曲唑对多囊卵巢综合征促排卵88例临床分析.docVIP

二甲双胍联合来曲唑对多囊卵巢综合征促排卵88例的临床分析 　　[摘要] 目的 观察二甲双胍联合来曲唑对多囊卵巢综合征促排卵的临床效果。方法 选择2013年1月―2014年9月在该院治疗的88例具有胰岛素抵抗及氯米芬抵抗的多囊卵巢综合征（PCOS）患者随机分为对照组50例和实验组38例。对照组以来曲唑治疗，实验组以二甲双胍联合来曲唑治疗，各组均治疗3个周期后，观察两组患者治疗中排卵情况。结果 实验组恢复排卵率81.58%（31/38）高于对照组64%（32/50）（P0.05），差异有统计学意义（P0.05）。结论 二甲双胍联合来曲唑可改善多囊卵巢综合征患者胰岛素抵抗症状及内分泌紊乱，对氯米芬抵抗患者促排卵有效，比单用来曲唑促排卵更能提高排卵率。 　　[关键词] 多囊卵巢综合征；二甲双胍；氯米芬；来曲唑；排卵 　　[中图分类号] R711.75 [文献标识码] A [文章编号] 1674-0742（2015）02（b）-0117-02 　　The clinical effects of metformin and letrozole in ovulation for polycystic ovary syndrome 　　WANG Guizhi1 WANG Xuemei2 　　1.Department of Gynecology and Obstetrics ，The First Peoples Hospital of Wancheng District of Nanyang in Henan province ，Nanyang，473000 China 　　2.Reproductive center of Henan Provincial Matermal and Child Health Hospital， Zhengzhou 450052， China 　　[Abstract] Objective To observe the clinical efficacy of ovulation induction of the patients with polycystic ovary syn-drome（PCOS） treated by Metformin Combined with Letrozole； Methods 88 PCOS patients with Insulin and clomiphene resistant patients were divided into observation group（50 cases） and control group（38 cases ） .randomly-control group was treated by letrozole，experimental group was treated by metformin combined with letrozole ，the ovulation of each group was observed after three-month treatment. Results The experimental group restore ovulation rate 81.58%（31/38）was higher than that of control group64%（32/50）（P 0.05），the change had significant difference（P 0.05）. Conclusion United to can improve resistance syndrome in patients with symptoms and endocrine disorders in patients with PCOS ，in clomiphene resistant patients with ovulation effectively，than single letrozole ovulation can improve the ovulation rate. 　　[Key words] Polycystic ovary syndrome；Metformin；Clomiphene；Letrozole；Ovalation 　　多囊卵巢综合征（PCOS）是一种常见的妇科内分泌疾病。在临床上以雄激素过高的临床或生化表现、持续性无排卵、卵巢多囊改变为特征，常伴有胰岛素抵抗（IR）和高胰岛素血症（HI）及肥胖[1]。该研究选取2013年1月―2014年9月在该院治疗的患者，用二甲双胍联合来曲唑治疗PCOS，观察其对胰岛素抵抗及氯米芬抵抗的患者排卵情况，获得良好效果，现报道如下。 　　1