乙型肝炎肝硬化患者血清自身抗体检测临床意义.docVIP

乙型肝炎肝硬化患者血清自身抗体检测的临床意义 　　[摘要] 目的 探讨乙型肝炎肝硬化患者血清自身抗体的存在情况及其临床意义。方法 选取2016年3月～2017年6月青岛市第六人民医院门诊及住院的乙型肝炎肝硬化患者60例，采用免疫印迹法检测患者血清自身抗体，并根据自身抗体检测结果分为自身抗体阳性组（n=13）和自身抗体阴性组（n=47），采用全自动生化分析仪检测两组肝功能指标（ALT、AST、TBil、AKP、GGT）及免疫球蛋白，并进行肝脏瞬时弹性硬度检测（Fibroscan）。 结果 乙型肝炎肝硬化患者自身抗体总检出率为21.7%。与自身抗体阴性组比较，自身抗体阳性组年龄增大（P 0.05），GLB、IgG、Fibroscan值显著升高（P 0.05），ALB降低（P 0.05）。 结论 乙型肝炎肝硬化患者存在自身免疫反应，导致自身抗体的产生，其与患者的年龄、肝脏损伤及肝纤维化程度有关。 　　[关键词] 乙型肝炎肝硬化；自身抗体；抗核抗体；自身免疫反应 　　[中图分类号] R512.6 [文献标识码] A [文章编号] 1673-7210（2017）10（b）-0121-04 　　Clinical significance of serum autoantibodies detection in patients with hepatitis B cirrhosis 　　YAN Xiuping HOU Qingshun WANG Hui GUO Lu 　　Liver Disease Ten Area， the Sixth People′s Hospital of Qingdao City， Shandong Province， Qingdao 266033， China 　　[Abstract] Objective To explore the presence of serum autoantibodies in patients with hepatitis B cirrhosis and its clinical significance. Methods 60 patients with hepatitis B cirrhosis in the Sixth People′s Hospital of Qingdao City from March 2016 to June 2017 were selected and divided into autoantibodies positive group （n=13） and autoantibodies negative group （n=47） according to the test results of serum autoantibodies which were detected with immunoblot. The liver function indexes of ALT， AST， TBil， AKP， GGT and immunoglobulin between two groups were detected by using full automatic biochemical analyzer. Liver instantaneous elastic hardness （Fibroscan） was tested. Results Total positive rate of autoantibodies in patients with hepatitis B cirrhosis was 21.7%. Compared with autoantibody negative group， the age of autoantibody positive group was increased （P 0.05）， the levels of GLB， IgG and Fibroscan were significantly increased in autoantibody positive group （P 0.05）， ALB of autoantibody positive group was decreased （P 0.05）. Conclusion Autoimmune reactions exist in patients with hepatitis B cirrhosis， and cause production of autoantibodies， which are related to the age， the degree of liver damage and liver fibros