全身麻醉苏醒期静注曲马多预防躁动的效果观察.docVIP

全身麻醉苏醒期静注曲马多预防躁动的效果观察 　　[摘要] 目的 观察曲马多对麻醉苏醒期躁动的治疗效果及安全性。 方法 选择我院2011年1月～2014年1月收治入院的200例ASAⅠ～Ⅱ级患者，均行择期上腹部手术，将其随机分为两组，每组100例。观察组患者给予静注曲马多1.5 mg/kg，对照组仅给予静注生理盐水2 ml。记录患者苏醒期的躁动情况，麻醉前基础值、术毕、气管拔管时和拔管后10 min时的心率和平均动脉压（MAP）。观察比较两组患者不良反应发生情况。 结果 两组患者干预后与麻醉前基础值比较，气管拔管时两组心率、MAP明显升高，差异有统计学意义（P0.05）；与对照组比较，观察组中重度躁动的比率显著降低（χ2=4.073，P0.05）；观察组与对照组发生恶心呕吐的比率分别为10%（10/100）、7%（7/100），两组比较差异无统计学意义。 结论 曲马多治疗全身麻醉苏醒期躁动效果好，给药安全性高，值得临床推广。 　　[关键词] 曲马多；全身麻醉；苏醒期躁动；心率；安全性 　　[中图分类号] R614.2 [文献标识码] A [文章编号] 1674-4721（2016）01（b）-0100-03 　　Effects observation on intravenous injection of tramadol at emergence of general anesthesia in prevention of agitation 　　ZHOU Qian LV Dong-sen YUAN Cheng-cheng KANG Li LUO Fen LIU Huan-jie LIU Hua 　　Department of Anesthesiology，Traditional Chinese Medicine Hospital of Baoan District in Shenzhen City，Shenzhen 518100，China 　　[Abstract] Objective To observe the therapeutic effects and safety of tramadol in emergence agitation of general anesthesia. Methods 200 patients with ASA grade Ⅰ to Ⅱ treated by upper abdominal surgeries in our hospital from January 2011 to January 2014 were selected and randomly divided into two groups（100 patients in each group）.Patients in the observation group were treated by intravenous injection of tramadol 1.5 mg/kg，while patients in the control group were only intravenously injected by normal saline 2 ml.The emergence agitation，heart rates and mean arterial pressure（MAP） before and after operation，and at tracheal extubation and 10 min after extubation were recorded.The incidence of adverse event was statistically analyzed. Results Compared with the baseline values before anesthesia，after intervention，the heart rates and MAP at tracheal extubation were statistically significant enhanced（P0.05）.Compared with the control group，the incidence of severe agitation in the observation group was significantly reduced （χ2=4.073，P0.05）.The incidences of nausea and vomiting in the observation group and control group was 10%（10/100） and 7% （