二甲双胍与炔雌醇环丙孕酮片联用在多囊卵巢综合征治疗中疗效探析.docVIP

二甲双胍与炔雌醇环丙孕酮片联用在多囊卵巢综合征治疗中的疗效探析 　　【摘要】 目的：探讨二甲双胍与炔雌醇环丙孕酮片联用在多囊卵巢综合征治疗中的临床疗效。方法：选取2015年5月-2016年5月本院收治的多囊卵巢综合征患者72例作为研究对象，根据不同治疗方法分为对照组和研究组，每组36例。对照组采用炔雌醇环丙孕酮片治疗，研究组采用二甲双胍与炔雌醇环丙孕酮片联合治疗，比较分析两组治疗疗效。结果：两组治疗后黄体生成素（LH）、睾酮（T）、雌激素（E2）、空腹胰岛素（FINS）、胰岛素抵抗指数（HOMA-IR）均较治疗前降低，且研究组低于对照组，比较差异均有统计学意义（P0.05）；研究组治疗后月经恢复率、排卵率、妊娠率及临床总有效率均优于对照组，比较差异均有统计学意义（P0.05）。结论：二甲双胍与炔雌醇环丙孕酮片联合用于多囊卵巢综合征治疗临床疗效显著，值得临床推广。 　　【关键词】 二甲双胍； 炔雌醇环丙孕酮片； 多囊卵巢综合征 　　【Abstract】 Objective：To investigate the clinical curative effect of Metformin and Ethinylestradiol Cyproterone Acetate Tablets in the treatment of polycystic ovary syndrome.Method：From May 2015 to May 2016，72 cases of polycystic ovary syndrome in our hospital were selected as the research objects，they were divided into the control group and the study group according to different treatment methods，each group had 36 cases.The control group was given Ethinylestradiol Cyproterone Acetate tablets treatment and the study group was given Metformin and Ethinylestradiol Cyproterone Acetate Tablets combination treatment，the therapeutic efficacy of two groups were compared and analyzed.Result：Two groups after the treatment of luteinizing hormone（LH），testosterone（T），estrogen （E2），fasting insulin（FINS），insulin resistance index（HOMA-IR） were lower than before treatment，and the study group were lower than the control group，the differences were statistically significant（P0.05）.After treatment，the menstruation recovery rate，ovulation rate，pregnancy rate and clinical total effective rate of the study group were better than those of the control group，the differences were statistically significant（P0.05）.Conclusion：The clinical effect of Metformin combined with Ethinylestradiol Cyproterone Acetate Tablets in the treatment of polycystic ovarian syndrome have significant effect，it is worthy of clinical promotion. 　　【Key words】 Metformin； Ethinylestradiol Cyproterone Acetate Tablets； Polycystic ovary syndrome 　　First-author’s address：The Maternal and Child Health Care H