代谢综合征与肝胆恶性肿瘤相关性Meta分析.docVIP

代谢综合征与肝胆恶性肿瘤相关性的Meta分析 　　[摘 要] 目的：系统评价代谢综合征与肝胆恶性肿瘤相关性。方法：检索中国学术期刊网络出版总库和中国生物医学文献数据库（CBM）、Pubmed、EMbase，收集有关代谢综合征与肝癌、胆囊癌、胆管癌关系的文献，检索时限均为从建库至2015年6月。由2名研究者根据纳入和排除标准独立筛选文献，提取资料，并在评价纳入文献方法学质量后，用Stata 11.0软件进行Meta分析。结果：纳入8篇文献（5篇队列研究和3篇病例对照研究）Meta分析结果显示：代谢综合征患者的肝胆恶性肿瘤发生率高[RR=1.71，95%CI（1.42-2.06），P=0.000]；分层分析发现，男性人群中，代谢综合征肝胆恶性肿瘤发生率高于对照组[RR=1.55，95%CI：（1.21，1.99），P=0.001]，女性人群中，其合并效应量为[RR=1.48，95%CI（0.73，3.01），P=0.282），差异无统计学意义。结论：代谢综合征是肝胆恶性肿瘤发生的危险因素之一，且存在性别差异。 　　[关键词] 代谢综合征；肝癌；胆囊癌；胆管癌；Meta分析 　　中图分类号：R735 文献标识码：A 文章编号：2095-5200（2016）02-001-04 　　[Abstract] Objective：To evaluate the correlation between metabolic syndrome and hepatobiliary malignancy. Methods：Chinese Academic Journal Web Publishing Pool， Chinese Biomedical Literature Database （CBM）， PubMed and EMbase were searched， literature about the relationship between metabolic syndrome and liver cancer， gallbladder， and bile duct carcinoma were collected， and the retrieval time were all from building the database to June 2015. According to inclusion and exclusion criteria， 2 researchers screened the literatures independently， extracted data and evaluated methodological quality of the included studies， and used software of Stata 11.0 for Meta-analysis. Results：Eight documents were included （five cohort studies and 3 case-control studies）， and the results of meta analysis showed that： Metabolic syndrome in patients with high incidence of liver cancer and gallbladder carcinoma [RR=1.71，95% CI （1.42-2.06）， P=0.000]； stratified analysis found that， the incidence of liver cancer and gallbladder carcinoma of metabolic syndrome was higher than that of control group in the male[RR=1.55， 95% CI：（1.21，1.99），P=0.001]， and that in the female was combined effect amount [RR=1.48，95% CI（0.73，3.01），P=0.282）， and the difference was not statistically significant. Conclusions：The metabolic syndrome is one of the risk factors for liver and gallbladder malignancy， and there were gender differences. 　　[Key words] metabolic syndrome；liv