人工流产术前阴道应用米索前列醇片疗效观察.docVIP

人工流产术前阴道应用米索前列醇片的疗效观察 　　[摘要] 目的 观察人工流产术前阴道应用米索前列醇片的临床疗效及安全性。 方法 选取2012年3月～2013年3月本站收治的人工流产患者60例为研究对象，将其随机分为实验组和对照组，每组各30例。对照组患者术前给予常规对症治疗，实验组患者术前在此基础上经阴道给予米索前列醇片。比较两组患者的临床疗效及不良反应发生情况。 结果 实验组患者宫口扩张明显，有效率可达96.67%（29/30），显著高于对照组的33.33%（10/30），术中不需要进一步局部麻醉，出血量[（7.0±3.1）ml]显著低于对照组[（12.1±4.9）ml]（P0.05）。 结论 人工流产术前阴道应用米索前列醇片能够显著提高临床疗效，且安全性高，可在临床推广应用。 　　[关键词] 早孕产妇；人工流产；米索前列醇片；临床疗效；安全性 　　[中图分类号] R169.42 [文献标识码] A [文章编号] 1674-4721（2014）04（a）-0069-02 　　[Abstract] Objective To observe the clinical efficacy and safety of misoprostol tablet applied before artificial abortion through vaginal. Methods 60 patients with artificial abortion from March 2012 to March 2013 in our hospital were selected as the study objects and they were divided into the experimental group （n=30） and the control group （n=30）.The control group was given conventional symptomatic treatment before operation while the the experimental group was given misoprostol tablet through vaginal on the basis of the control group.The clinical efficacy and adverse reactions of the two groups were compared. Results The uterus mouth of patients expanded obviously in the experimental group，and the effective rate [ 96.67% （29/30）] was obviously higher than that in the control group [33.33% （10/30）]，and the experimental group had no further local anesthesia during operation，the amount of bleeding in the experimental group [（7.0 ± 3.1 ） ml] was significantly lower than the control group of patients [（12.1 ± 4.9） ml] （P0.05）. Conclusion Taking misoprostol tablet before a abortion can significantly improve the clinical efficacy with higher safety，and it can be promoted and applied in the clinic. 　　[Key words] Maternal of early pregnancy；Artificial abortion；Misoprostol tablet；Clinical efficacy；Safety 　　妊娠3个月内采用人工或药物方法终止妊娠称为早期妊娠终止，也可称为人工流产[1]，其用来作为避孕失败而意外妊娠的补救措施，也用于因疾病不宜继续妊娠、为预防先天性畸形或遗传性疾病而需终止妊娠者。随着医学技术的不断发展，人工流产术前应用一些宫颈扩张类药物，以试图减少患者的病痛，使手术操作顺畅[2]。米索前列醇片是宫颈扩张类药物的一种代表药。本研究对实施人工流产的30例患者术前应用米索前列醇片，评估人工流产术前阴道应用米索前列醇片的临床疗效及安全性。