去氧孕烯炔雌醇口服对原发性痛经的有效性及安全性探究.docVIP

去氧孕烯炔雌醇口服对原发性痛经的有效性及安全性探究 　　【摘要】目的：探究去氧孕烯炔雌醇口服对原发性痛经的有效性与安全性。方法：选择2012年9月至2013年9月我院原发性痛经患者98例，将所选患者随机分为A、B两组，每组49例。A组口服去氧孕烯炔雌醇治疗；B组口服安慰剂治疗，每组治疗3个周期。观察并比较两组治疗效果。结果：A组治疗总有效率为9184 %（45/49）；B组治疗总有效率为 7755%（48/49），A组显著高于B组，差异有统计学意义（χ2 = 3857，P005）；治疗后A组患者的TDS得分为（11±05）分，明显低于B组的（28±07）分，两组比较差异有统计学意义（t = 13755，P 005）。结论：去氧孕烯炔雌醇口服可有效治疗原发性痛经，可有效缓解患者疼痛，治疗比较安全，值得临床推广应用。 　　【关键词】避孕药；去氧孕烯炔雌醇；原发性痛经 　　Analysis of the efficacy and safety of oral contraceptives marvelon on patients with primary dysmenorrheaCHEN Yaqun1， SONG Xuejun2， FANG Xing3. 1. Department of Gynaecology and Obstetrics， Red Cross Hospital in Yuyao City， Ningbo 315450， China； 2. Department of Gynaecology and Obstetrics， Yuyao City People’ Hospital， Ningbo 315450， China； 3. Department of Gynaecology and Obstetrics， Jinhua City People’ Hospital， Jinhua 321000， China 　　【Abstract】Objectives： To analyze the efficacy and safety of oral contraceptives Marvelon on patients with primary dysmenorrhea. Methods： 98 patients with primary dysmenorrheal treated in our hospital from September 2012 to September 2013 were selected and divided into group A and B randomly， with 49 patients in each group. Group A was given contraceptives Marvelon for treatment and group B was given placebo for treatment， 3 courses for each group. The effects of the two groups were observed and compared. Results： The total efficiency rate of group A was 91.84 % （45/49）， which was higher than group B （77.55%， 48/49）， with statistically significant difference （χ2 = 3.857， P005） before treatment. The TDS scores of group A was （1.1±05）， lower than （2.8±07） in group B and the difference was statistically significant （t = 13.755， P005）. Conclusion： Oral contraceptives Marvelon is efficient and safe in treating patients with primary dysmenorrhea， which can effectively relieve pain of patients and is worthy of clinical application. 　　【Key words】Contraceptives； Marvelon； Primary dysmenorrhea 　　【中图分类号】R71151【文献标志码】A 　　原发性痛经是指女性生殖器官无明显器质性改变的经行小腹疼痛，且随月经周期而发作