依达拉奉治疗对颅内动脉瘤患者显微术后神经功能改善研究.docVIP

依达拉奉治疗对颅内动脉瘤患者显微术后神经功能的改善研究 　　[摘要] 目的 研究分析依达拉奉治疗对颅内动脉瘤患者显微术后神经功能的改善效果。 方法 试验中方便选取该院2013年5月―2016年10月收治的72例颅内动脉瘤患者，将全部患者随机分成研究组与对照组，均为36例；入选患者均行显微夹闭术进行治疗，对照组在手术后实施常规治疗，研究组在常规治疗的基础上联用依达拉奉，观察分析患者的神经功能改善情况、大脑中动脉血流速度（VMCA）及其预后情况等。结果 全部入选患者的治疗均完成后，在术后4周，研究组的NIHSS评分为（3.63±1.37）分，对照组为（5.75±1.46）分，研究组明显低于对照组（P0.05），且在术后4周，研究组的VMCA为（74.80±5.20），BMI评分为（86.35±9.71）分，对照组分别为（85.20±5.80），（65.38±8.68）分，组间对比，研究组均优于对照组（P0.05）；不良反应发生情况分析对比，研究组（2.78%）较对照组（16.67%）也明显减少（P0.05）。结论 颅内动脉瘤患者在行显微术后给予依达拉奉进行治疗，具有显著的临床效果，能够对患者的神经功能进行有效的改善。 　　[关键词] 依达拉奉；颅内动脉瘤；显微术；神经功能 　　[中图分类号] R651 [文献标识码] A [文章编号] 1674-0742（2017）02（b）-0143-03 　　[Abstract] Objective To research the edaravone treatment for patients with intracranial aneurysm on the improvement of neurologic function after the microscopy. Methods Convenient selection 72 cases of patients with intracranial aneurysm admitted and treated in our hospital from May 2013 to October 2016 were selected and randomly divided into two groups with 36 cases in each， all selected patients were treated with microsurgical clip occlusion， and the control group adopted the routine treatment after operation， while the research group adopted the edaravone on the basis of the routine treatment， and the improvement of neurologic function and VMCA and prognosis of patients were observed and analyzed. Results After treatment， the NIHSS score in the research group was obviously lower than that in the control group at 4 weeks after operation[（3.63±1.37）points vs（5.75±1.46）points]，（P0.05）， and the VMCA and BMI scores in the research group were better than those in the control group[（74.80±5.20），（86.35±9.71）points vs （85.20±5.80）， （65.38±8.68）points]（P0.05） and the occurrence of adverse reactions in the research group was obviously lower than that in the control group（2.78% vs 16.67%）（P0.05）. Conclusion The clinical effect of edaravone treatment for patients with intracranial aneurysm after the microscopy is obvious， which can effectively improve the neurologic function o