依达拉奉对脑梗死患者血清高敏C反应蛋白肿瘤坏死因子水平影响.docVIP

依达拉奉对脑梗死患者血清高敏C反应蛋白、肿瘤坏死因子水平的影响 　　【摘要】 目的 观察脑梗死患者应用依达拉奉对血清高敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)水平的影响。方法 50例急性脑梗死患者,随机分为治疗组(依达拉奉+常规治疗)和对照组(常规治疗),于治疗前和治疗后10 d检测血清高敏C反应蛋白、肿瘤坏死因子水平,并对治疗前、后的数据进行比较。结果 两组急性脑梗死患者血清hs-CRP和TNF-α水平在治疗前均高于健康体检组,差异具有统计学意义；而两组间比较差异无统计学意义。治疗后两组患者血清hs-CRP和TNF-α水平均下降,治疗组下降明显,与对照组相比差异具有统计学意义。结论 监测血清hs-CRP和TNF-α水平有助于判断脑梗死的预后；应用依达拉奉治疗可以显著降低患者血清血清hs-CRP和TNF-α水平,从而减轻脑组织损伤,有利于脑梗死患者的转归。 　　【关键词】 脑梗死;依达拉奉;高敏C反应蛋白;肿瘤坏死因子 　　 　　Influence of using edaravone on serum high sensitivity C-reactive protein and tumor necrosis factor-α levels in patients with cerebral infarction 　　FAN Li-jun,DAI Yan.Department of Neurology,the Third Hospital of Dalian,Liaoning 116037,China 　　【Abstract】 Objective To observe the influence of using edaravone on serum high sensitivity C-reactive protein and tumor necrosis factor-αlevels in patients with cerebral infarction.Methods 50 patients with acute cerebral infarction were divided into two groups randomly,treatment group and control group.The levels of serum high sensitivity C-reactive protein and tumor necrosis factor-α were measured before and after treatment.Results The levels of serum hs-CRP and TNF-α in cerebral infarction patients were marked higher than that in physical examination group.Compared with the control group,the levels of serum tumor necrosis factor-α and high sensitivity C-reactive protein were decreased significantly in treatment group,at d10 after treatment.Conclusion The serum hs-CRP and TNF-α can be a sensitive index in the patients with cerebral infarction.The levels of serum Tumor Necrosis Factor-α and high sensitivity C-reactive protein in patients with cerebral infarction can be decreased significantly by using edaravone. 　　【Key words】 Cerebral infarction; Edaravone; High sensitivity C-reactive protein(hs-CRP); Tumor necrosis factor-α(TNF-α) 　　 　　脑梗死是严重危害人民身体健康的疾病，其发病率、致残率均高,是三大致死疾病之一，因而寻找有效的治疗一直是人们关注的热点问题。炎性反应在脑梗死的病理机制中有着重要的作用，炎性介质与急性脑梗死之间关系已被越来越多的学者所重视。作为炎性介质的高敏C反应蛋白(hs-CRP) 、肿瘤坏死因子-α(TNF-α)在急性脑梗死发病的过程中可