依达拉奉联合天麻素治疗急性一氧化碳中毒临床研究.docVIP

依达拉奉联合天麻素治疗急性一氧化碳中毒的临床研究 　　【摘要】目的 探讨依达拉奉联合天麻素治疗急性一氧化碳中毒的临床疗效。方法以我科收治的100例急性一氧化碳中毒患者作为研究对象，随机分为观察组和对照组各50例，对照组给予常规和高压氧治疗；观察组在对照组的基础上加用依达拉奉和天麻素进行治疗，治疗2w后比较两组的疗效。结果观察组的有效率为96.0%，明显优于对照组（P0.05）,差异有统计学意义；并且在治疗后第5min、15min和30min，观察组动脉血氧分压改善情况明显优于对照组P0.05）,差异有统计学意义。结论依达拉奉联合天麻素治疗急性一氧化碳中毒疗效显著，能迅速改善脑组织缺氧状态，改善预后，值得临床上推广使用。 　　【关键词】依达拉奉；天麻素；急性一氧化碳中毒 　　 　　The clinical study of edaravone combined with gastrodin in treatment of acute carbon monoxide poisoning 　　 　　【Abstract】Objective To observe the clinical efficacy of edaravone combined with gastrodin in treatment of acute carbon monoxide poisoning. Methods100 patients with acute carbon monoxide poisoning in our department were divided into the observation group and the control group(50 cases in each group); the control group were treated by conventional therapy and high pressure oxygen; the observation group were added edaravone(30mg/1 time，2times/d) and gastrodin(0.6g/1 time,1 time/d) ,ivdrip,for two weeks. The clinical efficacies of the two groups were compared after two weeks. Results The total effective rate of the observation group(96.0%) was better than the control group(82.0%),the difference was statistically significant(P0.05); the changes of intracranial arterial oxygen pressure in the observation group after 5min、15min and 30 min of treatment were better than the control group(P0.05), the difference was statistically significant. Conclusion The clinical efficacy of edaravone combined with gastrodin in treatment of acute carbon monoxide poisoning is better, it can improve the patients cerebral hypoxia rapidly; it is worth to be widely used clinically. 　　【Keywords】edaravone ; gastrodin; acute carbon monoxide poisoning 　　 　　研究表明一氧化碳中毒患者脑细胞中过氧化物质及活性自由基等含量明显增加，而谷胱甘肽过氧化酶和过氧化氢酶等抗氧化酶类含量则显著降低，因此如何改善脑组织缺氧，清除过氧化物及自由基是治疗急性CO的重点[1]。我科自2009年1月~2011年3月研究了依达拉奉联合天麻素治疗急性CO中毒的临床疗效，取得了满意效果，现做如下报道： 　　1资料和方法 　　1.1临床资料 　　100例急性CO中毒患者，男56例，女44例；年龄8~72（平均40.6）岁；中中毒程度：轻度29例，中度39例，重度32例。随机分为观察组和对照组各50例，两组患者性别、年龄等一般情况间的差异不显著（P0.05）,具有