前列地尔联合依达拉奉治疗老年性椎基底动脉供血不足疗效观察.docVIP

前列地尔联合依达拉奉治疗老年性椎基底动脉供血不足疗效观察 　　【摘要】 目的 观察前列地尔联合依达拉奉注射液治疗老年性椎基底动脉供血不足的疗效。 方法 92例老年性椎基底动脉供血不足患者随机分为前列地尔联合依达拉奉治疗组(47例)和低分子右旋糖苷加复方丹参注射液对照组(45例),观察临床疗效及治疗前后彩色多普勒超声检测椎动脉血流参数的改变。 结果 治疗组痊愈35例(74%),对照组痊愈7例(15%),两组有统计学差异(P0.05),治疗组总有效率(100%)亦高于对照组(77%);治疗组中治疗后椎动脉各血流参数均较治疗前明显改善(P0.05),且两组治疗后相比,治疗组各参数均明显较对照组改善(P0.05)。结论 应用前列地尔联合依达拉奉治疗老年性椎基底动脉供血不足患者疗效显著,值得推广使用。 　　 【关键词】 前列地尔;依达拉奉;椎基底动脉供血不足 　　 　　Effects of Alprostadil and Edaravone combination therapy on the Disease of Vertebro-basilar Artery Insufficient Perfusion in Aged 　　LUO Dan-feng, LU Rui-yan, LUO Qi-yun,et al.Department of Neurology, the Second Affiliated Hospital of Sun Yet-sen University, Guangzhou 510120,China 　　 　　【Abstract】 Objective To study the value of Alprostadil and Edaravone injection in the treatment of Vertebro-basilar artery insufficiency (VBI).Methods 92 patients of VBI were randomly divided into two groups, Alprostadil and Edaravone therapy group (47 patients) and control group (45 patients).Results In the Alprostadil and Edaravone therapy group, 35 cases(75%) were cured,in the control group, 7 cases (15%) were cured, there was statistic difference in the two groups (P0.05).The effective rate of Alprostadil and Edaravone therapy (100%) was also higher than that of control group (77%), in the treatment group each parameter (including D,SPV,EDV,PI,RI of VA) after treatment was better improved than that before treatment (P0.05), and also these parameters were better than that after treatment in the control group (P0.05).Conclusion Compared with the traditional treatment, Alprostadil and Edaravone combination therapy has much more remarkable curative effect in treatment of VBI, and it is worthy of being wildly used. 　　【Key words】 Alprostadil; Edaravone; Vertebro-basilar artery insufficiency 　　 　　椎基底动脉供血不足(Vertebro-basilar artery insufficiency, VBI)是一种中老年人常见的脑血管疾病,临床表现为突发性、剧烈性眩晕,伴有头昏、恶心、呕吐、肢体无力、复视和吞咽困难等,症状常常反复发作,治疗有一定的难度[1]。本科近年多来采用前列地尔联合依达拉奉注射液治疗VBI患者例,疗效满意,现报道如下。 　　 　　1 对象与方法 　　 　　1.1 研究对象 选取20