初诊肺癌患者血清IL―8FractalkineMIP―3α表达与肺癌临床特征相关性分析.docVIP

初诊肺癌患者血清IL―8、Fractalkine、MIP―3α表达与肺癌临床特征的相关性分析 　　[摘要] 目的 分析初?\肺癌患者血清白细胞介素-8（IL-8）、趋化因子（Fractalkine）、巨噬细胞炎性蛋白-3α（MIP-3α）表达与肺癌临床特征的相关性。 方法 回顾性分析大连大学附属中山医院2013年1月～2015年12月收治的90例初诊肺癌患者（初诊肺癌组，其中小细胞癌21例、非小细胞癌69例）和同期门诊体检结果无异常的90名健康者（健康组）的临床资料。首先比较初诊肺癌组和健康组血清IL-8、Fractalkine、MIP-3α水平；其次将初诊肺癌组患者根据Ⅰ+Ⅱ期和Ⅲ+Ⅳ期、小细胞癌和非小细胞癌进行分组，比较血清IL-8、Fractalkine、MIP-3α水平；最后采用Pearson相关检验分析初诊肺癌组患者血清IL-8、Fractalkine、MIP-3α三个指标之间的相关性。 结果 ①初诊肺癌组患者血清IL-8、Fractalkine、MIP-3α水平均明显高于健康组（均P 0.05）。④Pearson相关分析显示，IL-8与Fractalkine（r = 0.598，P 0.05）、IL-8与MIP-3α（r = 0.641，P 0.05）、Fractalkine与MIP-3α（r = 0.682，P 0.05）之间均存在线性相关性。 结论 初诊肺癌患者血清IL-8、Fractalkine、MIP-3α水平高于健康人员，且随着病情的加重而升高，但不同病理分型之间水平无显著差异，三个指标相互呈线性相关，可作为初诊肺癌患者病情判断的指标。 　　[关键词] 肺癌；白细胞介素-8；Fractalkine；巨噬细胞炎性蛋白-3α 　　[中图分类号] R734.2 [文献标识码] A [文章编号] 1673-7210（2017）12（b）-0092-04 　　[Abstract] Objective To analyze the correlation of the expression of serum interleukin-8 （IL-8）， chemotactic factor （Fractalkine）， macrophage inflammatory protein-3α （MIP-3α） and clinical features of lung cancer in patients with newly diagnosed lung cancer. Methods The clinical data of 90 patients with newly diagnosed lung cancer （newly diagnosed lung cancer group， 21 cases of small cell carcinoma and 69 cases of non small cell carcinoma） admitted to Zhongshan Hospital Affiliated to Dalian University from January 2013 to December 2015 and 90 healthy controls with normal results of outpatient physical examination at the same time （healthy group） was analyzed retrospectively. Firstly， the levels of serum IL-8， Fractalkine， MIP-3α between newly diagnosed lung cancer group and healthy group were compared. Secondly， the newly diagnosed lung cancer group was divided into different groups according to Ⅰ+Ⅱ stage and Ⅲ+Ⅳ stage， small cell carcinoma and non-small cell carcinoma， and the levels of serum IL-8， Fractalkine and MIP-3 were compared. At last， Pearson correlation test was used to analyze the relationship among the levels of serum IL-8， Fractalkine and MIP-3 in newly diagnos