前列地尔治疗高龄糖尿病合并慢性肾脏病效果探讨.docVIP

前列地尔治疗高龄糖尿病合并慢性肾脏病效果探讨 　　[摘要] 目的 探?前列地尔治疗高龄糖尿病合并慢性肾脏病的临床效果。方法 将该院在2014年7月―2015年7月收治的高龄糖尿病合并慢性肾脏病的患者中方便选取100例，并将其按照随机数字表法分为两组（n=50），对照组采用常规的诊治方法作为治疗手段，观察组则在常规诊治的基础上联合前列地尔进行治疗。结果 对两组患者血糖、血红蛋白、尿素氮、血肌酐、尿蛋白水平在治疗前后的变化，并进行对比。对比结果显示观察组患者和对照组患者的空腹血糖（FBG）、糖化血红蛋白（HbAlc）在治疗前后并差异无统计学意义（P0.05）；2组患者的尿素氮（BUN）、血肌酐（Scr）以及24 h尿蛋白水平在治疗前并差异无统计学意义（P0.05）；在治疗后，观察组患者尿蛋白排泄率（43.2±10.6）μg/min，对照组为（56.4±15.6）μg/min；观察组微量尿蛋白（86.1±23.4）μg/g、对照组（110.4±33.4）μg/g观察组患者明显高于对照组，差异有统计学意义（P0.05）。 结论 在高龄糖尿病结合慢性肾脏病的常规治疗基础上结合前列地尔辅助治疗，能够在减少不良反应的同时，对肾脏功能进行改善。 　　[关键词] 前列地尔；高龄糖尿病；慢性肾脏病；治疗效果；安全性；观察 　　[中图分类号] R587 [文献标识码] A [文章编号] 1674-0742（2017）11（c）-0130-03 　　[Abstract] Objective This paper tries to observe the clinical effect of alprostadil in the treatment of elderly patients with diabetes mellitus complicated with chronic kidney disease. Methods 100 cases of elderly patients with diabetes mellitus complicated with chronic kidney disease treated in this hospital from July 2014 to July 2015 were convenient selected and randomly divided into two groups （n=50） according to the random number table method. The control group adopted the conventional treatment， the observation group based on the conventional diagnosis added the alprostadil treatment. Results The changes of blood glucose， hemoglobin， urea nitrogen， serum creatinine and urinary protein levels before and after treatment were compared between the two groups. Contrast results showed that the fasting blood glucose （FBG） and glycosylated hemoglobin （HbAlc） of the patients in the observation group and the control group were not significantly different from those before treatment（P0.05）. The blood urea nitrogen（BUN）， serum creatinine （Scr）， and 24h proteinuria were significantly higher in the observation group than in the control group（P0.05）， After treatment， the urinary protein excretion rate of the observation group was （43.2±10.6）μg/min， and the control group was （56.4±15.6）μg/min. The observation group had urine protein of （86.1±23.4） μg/g， and th