利培酮联合艾司西酞普兰治疗慢性精神分裂症阴性症状对照研究.docVIP

利培酮联合艾司西酞普兰治疗慢性精神分裂症阴性症状对照研究 　　【摘要】目的探讨利培酮联合艾司西酞普兰治疗慢性精神分裂症阴性症状的临床疗效以及安全性。方法将80例以阴性症状为主的慢性精神分裂症患者随机分为合用组和单用组, 疗程12周, 采用阳性和阴性症状量表(PANSS)和治疗中出现的症状量表(TESS)评定疗效和安全性。结果合用组显效率77.5%, 单用组显效率55%。治疗后两组PASS评分均较治疗前有显著性下降, 差异有统计学意义(P0.05)。结论利培酮联合艾司西酞普兰治疗慢性精神分裂症阴性症状起效快、疗效好, 不良反应少。 　　【关键词】艾司西酞普兰；利培酮；慢性精神分裂症；阴性症状 　　 　　Control study on escitalopram combined with risperidone in the treatment of negative symptoms of chronic schizophrenia patients LI Xin-feng. Xinyang Mental Hospital, Xinyang 464000, China 　　【Abstract】Objective To evaluate clinical efficacy and safety of escitalopram combined with risperidone in the treatment of negative symptoms of chronic schizophrenia paitents. Methods Divided 80 patients with predominantly negative symptoms of chronic schizophrenia into combined group(escitalopram combined risperdone) and control group(risperidone alone) with 12 weeks treatment. PANSS and TESS were used to assess the efficacy and safety respectively. Results The significant improvement rate in combined group was higher(77.5% ) than control group(55%), compared with before treatment, PANSS scores decreasedsignificantly after treatment(P0.01). After 4 weeks treatment, the total scores and negative symptoms scores of PANSS significantly decreasaed in combined group compared to control group(P0.05) There were no significant differences in side effects between two groups. Conclusion Escitalopram combined with risperidone in the treatment of chronic schizophrenia with negative symptoms show rapid response, better efficacy and good patient compliance. 　　 【Key words】Escitalopram; Risperidone; Chronic schizophrenia; Negative symptoms 　　以阴性症状为主的慢性精神分裂症患者疗效差。非典型性抗精神病药物对精神分裂的阳性、阴性症状均有较好的疗效, 但对慢性精神分裂症阴性症状的疗效仍然不显著。文献报道新型抗抑郁药能增加对精神分裂症阴性症状的治疗效果［1, 2］。本研究使用利培酮联合艾司西酞普兰治疗慢性精神分裂症阴性症状, 现报告如下。 　　1资料与方法 　　1. 1一般资料为2012年1月~2012年12月在本科住院的患者。入组标准: ①符合中国精神障碍分类与诊断标准第3版(CCMD-3)精神分裂症诊断标准; ②病程＞5年；③以阴性症状为主, 阳性症状和阴性症状量表(PANSS)评分＞70分, 阴性症状分＞30分；④排除严重躯体疾病, 酒精和药物依赖以及药物过敏者。共80例患者。随机分为合用组(利培酮合用艾司西酞普兰)、单用组(单用利