化痰祛瘀法对痰浊瘀阻型急性冠脉综合征患者血小板活化功能影响研究.docVIP

化痰祛瘀法对痰浊瘀阻型急性冠脉综合征患者血小板活化功能影响研究 　　【摘要】 目的 观察化痰祛瘀法改善痰瘀阻络型的急性冠脉综合征患者的临床疗效及对血小板P-选择素水平的影响。方法 临床选取中医辩证为痰瘀阻络型的急性冠脉综合征患者78例,随机分为中药治疗组(39例)和对照组(39例)。采用流式细胞仪测定中药治疗前、治疗15 d及30 d血小板P-选择素的变化情况。结果 ①治疗后两组比较,治疗组疗效明显优于对照组,差异有统计学意义(P0.05);②两组患者经过治疗后血小板P-选择素水平均能明显下降(P0.05)。治疗后中药治疗组患者Ps水平明显低于对照组患者(P0.05)。结论 化痰祛瘀法能提高痰浊瘀阻型急性冠脉综合征疗效,与对照组比较,能更有效降低急性冠脉综合征患者的血小板P-选择素水平,提示具有抗血小板活化,防治血栓形成的功效,这可能是该法有效治疗急性冠脉综合征的作用机制之一。 　　【关键词】化痰祛瘀法;P-选择素;急性冠脉综合征;血小板活化 　　Effect of Expectorant and Dispel-gore Therapy on the level of platelet P-selectin in patients with acute coronary syndrome 　　 　　LIU Ning,YAO Fu-mei,LI Yong,et al.The Second People’s Hospital of Dalian,Dalian 116001,China 　　 　　【Abstract】 Objective To observe the effects of Expectorant and Dispel-gore therapy on thelevel of platelet P-selectin in patients with acute coronary syndrome and explore its possible mechanism.Methods 78 patients with ACS were randomly divided into two groups.39 cases were in control group taking routine therapy and 39 cases were in treatment group taking Huatanquyu decoction in the first day,besides basic treatment.Platelet P-selectin were measured in two groups treatment after the15th and the 30th days in the hospital.Results There was no significant difference in platelet P-selectin between the two groups before treatment(P0.05).On the 15th day and the 30th day the level of platelet P-selectin were all slightly increased in both groups(P0.05).Conclusion A changeable regularity of platelet P-selectin can be found within the patients of ACS in Expectorant and Dispel-gore therapy can have effects of inhibiting platelet activation. 　　【Key words】 Expectorant and Dispel-gore therapy; P-selectin; Acute coronary syndrome; Plateletactivation 　　 　　急性冠脉综合征(acute coronary syn-drome,ACS)是心血管临床的急危重症,死亡率和致残率极高[1],其病理基础是不稳定粥样斑块(易损斑块)的破裂、血栓的形成或伴有血管痉挛,血小板活化和内皮细胞功能失调在其中发挥了重要的作用[2]。P-选择素是细胞黏附分子选择素家族成员之一,在介导白细胞在内皮上黏附和聚集、血小板活化以及血栓形成过程中均发挥重要作用[3]。随着人们生活水平的提高,饮食结构的改变,急性冠脉综合征痰浊瘀阻证患者已日益增加。 　　 　　 　　本研究运用化痰祛瘀法治疗痰瘀阻络型急性冠脉综合征患者,通过观察其对