去铁胺治疗长期输血所致铁过载疗效观察.docVIP

去铁胺治疗长期输血所致铁过载疗效观察 　　摘要：目的 观察去铁胺治疗长期输血所致铁过载的临床疗效。方法 回顾分析2015年12月～2016年12月在我院接受治疗的36例长期输血所致铁过载患者临床资料，均采用去铁胺治疗，观察临床治疗疗效。结果 治疗1个月、3个月后铁蛋白水平均明显降低，与治疗前对比差异有统计学意义（P0.05），治疗3个月与治疗1个月对比差异有统计学意义（P0.05）；治疗3个月后临床总反映率明显高于治疗1个月，差异有统计学意义（P0.05）；治疗和观察期间，出?F2例头痛，1例呕吐，2例腹泻，不给于特殊处理后自行缓解，3例出现肝酶升高，经保肝治疗后恢复。结论 去铁胺治疗长期输血所致铁过载安全有效，值得临床推广和应用。 　　关键词：去铁胺；长期输血；铁过载 　　Efficacy of Deferoxamine in the Treatment of Iron Overload Caused by Long-term Transfusion 　　HAN Guang-yu 　　（Department of Oncology，Peoples Hospital of Jizhou District，Tianjin 301900，China） 　　Abstract：Objective To observe the clinical effect of deferoxamine treatment of long-term blood transfusion caused by iron overload.Methods A retrospective analysis of December 2015～2016 year in December in our hospital for treatment of 36 cases of long-term blood transfusion caused by clinical data in patients with iron overload，with deferoxamine treatment，observe the clinical curative effect.Results 1 months after treatment，3 months after the ferritin level reduced significantly，statistically significant compared with before treatment（P0.05），the difference was statistically significant for 3 months and 1 months of treatment differences（P0.05）；after 3 months of treatment was significantly higher than the total reflection of clinical treatment for 1 months，the difference was statistically significant（P0.05）；during the period of treatment and observation，there 2 cases of headache， vomiting in 1 cases，2 cases of diarrhea，do not give special treatment after remission，3 cases of elevated liver enzymes，the liver recovery after treatment. Conclusion Desferrioxamine treatment of iron overload caused by long-term blood transfusion is safe and effective，worthy of clinical promotion and application. 　　Key words：Deferoxamine；Long-term blood transfusion；Iron overload 　　严重贫血或特殊病患者需要长期依赖输血以改善贫血所致的缺氧状态，以提高患者的生存质量。长时间对红细胞输注的依赖，会导致患者出现铁过载问题，即机体对铁的摄入增加、利用障碍或相关基因突变等导致铁在脏器组织中的贮存增加[1]。铁过载会引起患者心脏、肝功能的衰竭以及内分泌紊乱，出现铁代谢失衡。因此，临床治疗长期输血所致铁过载具有重要的临床意义。本文作者结合2015年1