单羰基姜黄素类似物对Ⅱ型糖尿病大鼠非酒精性脂肪肝治疗作用研究.docVIP

单羰基姜黄素类似物对Ⅱ型糖尿病大鼠非酒精性脂肪肝治疗作用研究 　　摘要 [目的]研究单羰基姜黄素类似物（代号B06）对Ⅱ型糖尿病大鼠非酒精性脂肪肝糖脂代谢紊乱的影响。[方法]应用高糖高脂饲料喂养，小剂量STZ干扰建立Ⅱ型糖尿病大鼠模型[1]，并随机分模型组、A75治疗组、C66治疗组、正常对照组，各组均灌胃治疗12周；检测各组大鼠血生化指标[2]。[结果]单羰基姜黄素类似物能明显改善试验性Ⅱ型糖尿病大鼠的血糖升高，FINS明显低于模型组；肝脏TC、血清TG、TC有明显的降低作用，对血清HDL有明显的升高作用，有统计学意义；[结论]单羰基姜黄素类似物对Ⅱ型糖尿病大鼠非酒精性脂肪肝有一定的治疗作用。 　　关键词 单羰基姜黄素；Ⅱ型糖尿病；非酒精性脂肪肝；链脲佐菌素；治疗作用 　　中图分类号 R587.1 文献标识码 A 文章编号 1007-5739（2014）05-0276-03 　　Effect of Single Carbonyl Curcumin Analogues on Nonalcoholic Fatty Liver Disease in Type Ⅱ Diabetic Rats 　　HOU Jie 1 LIAO Min 2 YE Xian-cai 1 SHEN Zhong-fei 1 　　（1 Teaching and Research Section of Anatomy，College of Medicine，Jiaxing University，Jiaxing Zhejiang 314001； 2 Teaching and Research Section of Anatomy and Embryology，Wenzhou Medical University） 　　Abstract [Objective] To research the effect of single carbonyl curcumin analogues on nonalcoholic fatty liver disease in Type Ⅱ diabetic rats.[Method]Building the Type Ⅱ diabetic rats model that implicating with small dose of streptozotocin by raising heat breeding，randomly divided into model group，A75 treatment group，C66 treatment group，and normal control group，each rat was accordingly given lavage treatment for 12 weeks；then tested groups of sugar and lipid metabolism of blood biochemical indexes.[Results]In sugar metabolism，single hydroxyl curcumin analogues could obviously improve the experimental Type Ⅱ diabetic rats blood glucose，FINS significantly lower than the model group. In lipid metabolism，liver TC，serum TG and TC were significantly lower，serum HDL significantly increased，and it had statistical significance.[Conclusion]Single hydroxyl curcumin analogues for Type Ⅱ diabetes mellitus rats had a certain therapeutic effect of nonalcoholic fatty liver disease. 　　Key words single hydroxyl of curcumin；Type Ⅱ diabetes mellitus；nonalcoholic fatty liver disease；streptozotocin；therapeutic effect 　　Ⅱ型糖尿病是由于体内胰岛素相对不足或靶细胞对胰岛素敏感性降低所引起的内分泌代谢紊乱类疾病。调节糖皮质激素水平的关键酶11β-羟甾脱氢酶（11β-HSD）是催化糖皮质激素合成和转化的关键酶，直接控制着密切影响血糖水平和胰岛素功能的内分泌激素――