反复AIH失败后体外受精―胚胎移植应用观察.docVIP

反复AIH失败后体外受精―胚胎移植应用观察 　　【摘要】目的：通过回顾性分析反复夫精人工授精失败后患者行体外受精-胚胎移植的临床结局，为AIH反复失败后患者进行IVF-ET治疗提供临床依据。方法：选取西囡妇科医院生殖中心2015年3月份至2016年3月份所接收的107例进行两次以上人工授精并失败后行IVF-ET治疗的患者相关临床资料，并对其展开回顾性分析。结果：共实施取卵周期107个周期，新鲜胚胎移植周期共89周期，临床妊娠49例，临床妊娠率55.06%。IVF/ICSI 的助孕患者当中有95例患者采取了IVF受精方法，IVF受精失败患者9例，失败率为9.47%，改行早期补救ICSI后，仍有一例未能受精。其余12例直接采取ICSI方法受精，受精失败1例。结论：体外受精-胚胎移植方式用于反复人工授精失败患者的助孕临床治疗具有显著的效果，对IVF体外受精失败患者可通过实施短时受精联合早补ICSI治疗降低受精失败的风险，改善临床治疗结局。 　　【关键词】反复夫精人工授精失败；体外受精-胚胎移植；临床效果；分析 　　[Abstract] Objective：To retrospectively analyze the clinical outcomes of in vitro fertilization and embryo transfer （IVF） after failure of repeated insemination with husband and sperm， and to provide clinical evidence for IVF-ET treatment in AIH patients after repeated failures.Methods：the clinical data of 107 patients treated with IVF-ET in our hospital from March 2015 to March 2016 after the failure of two or more artificial insemination were analyzed retrospectively。Results：A total of 107 cycles were carried out， and the fresh embryo transplantation cycle was 89 cycles， of which 49 cases reached clinical pregnancy， and the clinical pregnancy rate was 55.06%。Among the IVF/ICSI assisted pregnancies， 95 patients underwent IVF fertilization and 9 failed IVF fertilization， with a failure rate of 9.47%， and one of the cases failed to be fertilized after undergoing an early remedy for ICSI. The other 12 cases were directly fertilized by ICSI， and 1 cases failed.Conclusion：In vitro fertilization and embryo transfer （IVF） have significant effects on the clinical treatment of pregnant women who have failed artificial insemination，Patients with IVF failure in vitro fertilization can reduce the risk of fertilization failure and improve the clinical outcome by short-term fertilization combined with early supplementation with ICSI. 　　[Key words] Repeated Artificial insemination failed In vitro fertilization and embryo transfer Clinical effect Analysis 　　【中?D分类号】R392.4 【文献标识码】B 【文章编号】2095-6851（2017）07-00-01 　　夫精人工授精（Ar