右美托咪定在重型颅脑外伤患者手术麻醉中脑保护效果分析.docVIP

右美托咪定在重型颅脑外伤患者手术麻醉中脑保护效果分析 　　【摘要】 目的：探究右美托咪定在重型颅脑外伤患者手术麻醉中的脑保护效果，为临床提供指导。方法：以来笔者所在医院就医的56例重型颅脑外伤患者（2015年5月13日-2016年12月13日）作为本次研究的观察对象，使用随机数字表法对56例患者进行分组。试验组28例患者在手术麻醉中应用右美托咪定，对照组28例患者在手术麻醉中应用生理盐水，研究对比两组重型颅脑外伤患者的血清S-100β蛋白水平及神经元特异性烯醇化酶水平。结果：试验组患者T1、T2、T3、T4的血清S-100β蛋白水平分别为（0.198±0.057）、（0.323±0.003）、（0.198±0.057）、（0.337±0.004）μg/L，相比对照组明显更低，差异有统计学意义（P0.05）；试验组患者T1、T2、T3、T4的神经元特异性烯醇化酶水平分别为（15.98±2.61）、（20.79±1.36）、（23.35±1.65）、（26.02±3.55）μg/L，相比?φ兆槊飨愿?低，差异有统计学意义（P0.05）。结论：在手术麻醉中，对重型颅脑外伤患者应用右美托咪定可在一定程度上改善脑氧代谢，具有一定的脑保护效果。 　　【关键词】 右美托咪定； 重型颅脑外伤； 手术麻醉； 脑保护； 效果 　　doi：10.14033/j.cnki.cfmr.2018.6.009 文献标识码 B 文章编号 1674-6805（2018）06-0019-02 　　The Cerebral Protection Effect of Dexmedetomidine for Patients with Severe Craniocerebral Trauma under Operative Anesthesia/LI Haibo.//Chinese and Foreign Medical Research，2018，16（6）：19-20 　　【Abstract】 Objective：To explore the cerebral protection effect of Dexmedetomidine for patients with severe craniocerebral trauma under operative anesthesia and provide clinical guidance.Method：56 patients with severe craniocerebral trauma who sought medical treatment in our department from May 2015 to December 2016 were enrolled for observation and divided in accordance with the random number table.28 cases in the experimental group were treated with Dexmedetomidine under operative anesthesia，while the rest 28 cases in the control group were treated with normal saline under operative anesthesia.The two groups were compared in terms of the levels of serum S-100β protein and neuronspecific enolase（NSE）.Result：The serum S-100β protein levels of the experimental group at T1，T2，T3 and T4 were （0.198±0.057）μg/L，（0.323±0.003）μg/L，（0.198±0.057）μg/L and （0.337±0.004）μg/L respectively，obviously lower than those of the control group（P0.05）.The NSE levels of the experimental group at T1，T2，T3 and T4 were （15.98±2.61）μg/L，（20.79±1.36）μg/L，（23.35±1.65）μg/L and （26.02±3.55）μg/L，remarkably lower than those of the control group（P0.05）.Conclusion：For patients wi