右美托咪定在骨科关节置换术全身麻醉中应用效果.docVIP

右美托咪定在骨科关节置换术全身麻醉中应用效果 　　[摘要]目的 探讨右美托咪定在骨科关节置换术全身麻醉中的应用效果。方法 选取我院2016年4月1日～2017年3月31日收治的74例骨科关节置换手术患者，随机分为观察组（右美托咪定静脉滴注）和对照组（等量生理盐水静脉滴注），各37例。观察组采用右美托咪定静脉滴注，对照组采用等量生理盐水?o脉滴注，比较两组骨科关节置换手术患者的MMSE评分、S100β水平、血流动力学以及不良反应发生情况。结果 观察组治疗后3 d、1周的MMSE评分、S100β水平与对照组比较，差异有统计学意义（P0.05）。观察组骨科关节置换手术患者T3、T4、T5时的HR以及T5时的CVP、MAP水平均低于对照组（P0.05）。观察组骨科关节置换手术患者的不良反应发生率低于对照组（P0.05）。结论 在骨科关节置换手术的全身麻醉中采用右美托咪定能够改善患者的认知功能和血流动力学指标，减少不良反应的发生，降压效果显著。 　　[关键词]骨科关节置换手术；右美托咪定；全麻；降压 　　[中图分类号] R614.2 [文献标识码] A [文章编号] 1674-4721（2017）12（b）-0119-03 　　[Abstract]Objective To investigate the application effect of Dexmedetomidine in general anesthesia of orthopedic joint replacement.Methods 74 patients undergoing orthopedic joint replacement who were admitted to our hospital from April 1，2016 to March 31，2017 were selected and randomly divided into the observation group and the control group，with 37 cases in each group.The observation group was given Dexmedetomidine intravenous infusion， and the control group was given intravenous infusion of equal volume of normal saline.The MMSE score，S100β level，hemodynamics and adverse events were compared between the two groups of patients undergoing orthopedic joint replacement.Results There was significant difference in the MMSE score and S100β level between the observation group at 3 days and 1 week after treatment and those in the control group （P0.05）.The levels of HR at T3，T4，T5 and CVP and MAP at T5 in the observation group in the patients undergoing orthopedic joint replacement were significantly lower than those in the control group （P0.05）.The incidence rate of adverse reactions in the patients undergoing orthopedic joint replacement in the observation group was lower than that in the control group （P0.05）.Conclusion The application of Dexmedetomidine in general anesthesia of orthopedic joint replacement can improve the cognitive function and hemodynamic indices of patients，reduce the incidence of adverse reactions，and the antihypertensive effect is signif