单纯放疗与宫颈植入性化疗协同放疗治疗老年宫颈癌临床疗效对比分析.docVIP

单纯放疗与宫颈植入性化疗协同放疗治疗老年宫颈癌临床疗效对比分析 　　【摘要】 目的 对比分析单纯放疗及应用植入性氟尿嘧啶同步放化治疗老年宫颈癌初治患者的疗效和并发症。方法 选择2006年11月至2007年5月在吉林省肿瘤医院收治的初治宫颈癌患者共58例，临床分期为Ⅰb-Ⅲb期，按治疗方法不同分为单纯放疗组（共30例，给予X线远距离治疗机体外照射及192 Ir 腔内后装治疗）和同步放化疗组（共28例，给予宫颈植入氟尿嘧啶缓释剂500~800 mg，同时给予X线远距离治疗机体外照射及192 Ir 腔内后装治疗），对两组患者的疗效及并发症发生情况进行对比分析。结果 单纯放疗组与同步放化疗组有效率分别为92%、86%，两组比较，差异有统计学意义（P0．05）。结论 宫颈植入性化疗协同放疗在不增加患者毒副反应的同时可明显改善老年宫颈癌患者的预后。? 　　【关键词】植入性化疗;放射疗法;宫颈癌 　　 　　Retrospective study of local area chemotherapy mach radiotherapy compared with radiotherapy alone for cervical canaer 　　 　　PU Jian-wen,GAO Chun-ying,PIAO Jin-xia,et al.Cancer Hospital，Gynecology.Changchun 130012,China 　　? 　　【Abstract】 Objective To compare the treatment effects and side events between local area chemotherapy mach radiotherapy and radiotherapy alone for cervical cancer.Methods Totally 58 patients with primary cervical in our hospital were seleoted from nov 2006 to may 2007.They were divided in to two groups： radiotherapy alone or local area chemotherapy mach radiotherapy.Group of radiotherapy alone included 30 patients who received external irradiation by X-rays and intracavitary by 192Ir.Croup of local area chemotherapy mach radiotherapy included 28 patients who received lcoal area chemotherapy mach radiotherapy.The radiotherapy alone regimen was the same as group local area chemotherapy mach radiotherapy.Results The local control (CR+PR) in two groups were 92%and 86%，with significant difference(P0．05).The common side effect was hematological toxicity in some patients ， which was not different in two groups.Grade 3 hematological toxicity were 3%and 0%(P0．05).Conclusion Local area chemotherapy mach radiotherapy may be effective for elder cervical cancer.? 　　【Key words】local area chemotherapy;Radiotherapy;Cervical cancer 　　 　　宫颈癌是最常见的妇科恶性肿瘤，中晚期宫颈癌，尤其老年宫颈癌患者放疗仍为治疗的首选方法，尽管近年来试图通过放、化疗联合治疗来改善患者的预后，并获得了肯定的疗效。但联合治疗无疑增加了患者的毒副反应，使老年患者不能耐受，如治疗中断，同样不能得到预期治疗效果。本研究采用宫颈植入性区域化疗同时配合放疗与单纯放疗比较两组治疗效果，毒副反应，现报道如下。 　　 　　1 临床资料 　　 　　1．1 一般资料 选取2006年11月至2007年5月在吉林省