同型半胱氨酸在不同疾病中临床意义.docVIP

同型半胱氨酸在不同疾病中临床意义 　　doi：10.3969/j.issn.1007-614x.2014.11.81 　　摘 要 目的：探讨同型半胱氨酸在不同疾病中的临床意义。方法：收治住院患者247例，根据临床诊断分为高血压组、糖尿病组、心梗组、脑梗组、肾病组。对所有入组患者分别检测Hcy、TC、TG、HDL和LDL。结果：各病例组男、女Hcy值与对照组男、女相比，差异有统计学意义（P0.05）外，糖尿病组、心梗组、脑梗组、肾病组男女间Hcy值差异均有统计学意义（P0.05）；男性心梗组、脑梗组Hcy值与糖尿病组、高血压组和肾病组差异有统计学意义（P0.05）。高血压组、糖尿病组、心梗组、脑梗组和肾病组Hcy水平与TC、TG、LDL无相关，与HDL水平降低有相关性（P0.05）。结论：Hcy列入上述疾病的常规检查和定期体检，做到早发现、早预防和早治疗，以减少心脑血管的危害。 　　关键词 同型半胱氨酸 高血压 糖尿病 　　Clinical significance of homocysteine in different diseases 　　Lv Haichao 　　Clinical Laboratory，Oil Field General Hospital of Henan（Nanyang City，Henan） 473132 　　Abstract Objective：To explore the clinical significance of homocysteine in different diseases.Methods：247 inpatients were selected.According to the clinical diagnosis，they were divided into hypertension group，diabetes group，myocardial infarction group，cerebral infarction group and nephropathy group.HCY，TC，TG，HDL and LDL of all patients were respectively detected.Results：The HCY value of male and female of all the case groups was compared with the male and female of the control group，the difference was statistically significant（P0.05）；in diabetes group，myocardial infarction group，cerebral infarction group and nephropathy group，the differences of HCY value between male and female were statistically significant（P0.05）；HCY values of male myocardial infarction group，cerebral infarction group had significant difference with diabetes group，hypertension group，and nephropathy group（P0.05）.The levels of HCY of hypertension group，diabetes group，myocardial infarction group，cerebral infarction group and nephropathy group had no correlation with TC，TG and LDL，and had correlation with decreased HDL levels（P0.05）.Conclusion：HCY should be listed in routine inspection and regular physical examination of the above diseases in order to achieve early discovery，early prevention and early treatment，so as to reduce the harm of cardiovascular and cerebrovascular diseases. 　　Key words Homocysteine；Hypertension；Diabet