单唾液酸四己糖神经节苷脂联合依达拉奉治疗脑出血保守治疗患者疗效观察.docVIP

单唾液酸四己糖神经节苷脂联合依达拉奉治疗脑出血保守治疗患者疗效观察 　　【摘要】 目的 观察单唾液酸四己糖神经节苷脂（博司捷）联合依达拉奉治疗脑出血保守治疗患者的临床疗效。方法 100例脑出血保守治疗患者， 按照随机数字表法分为观察组和对照组， 各50例。对照组在常规治疗的基础上加用神经保护剂博司捷;观察组在对照组的基础上加用依达拉奉;两组的疗程均为14 d。观察两组治疗前后神经功能缺损评分（NIHSS评分）、日常生活活动能力指数（Barthel指数）和血清超敏C反应蛋白（hs-CRP）水平的变化， 评价临床疗效。结果 治疗前两组的NIHSS评分、Barthel指数及血清hs-CRP水平差异无统计学意义（Pgt;0.05）;治疗后， 两组的NIHSS评分、Barthel指数及血清hs-CRP水平均较治疗前明显改善， 观察组改善情况明显优于对照组， 差异具有统计学意义（Plt;0.05）;观察组和对照组的临床总有效率分别为90%、72%， 观察组明显优于对照组， 差异具有统计学意义（Plt;0.05）。结论 博司捷联合依达拉奉能明显减轻脑出血保守治疗患者炎性反应， 改善神经功能和日常生活活动能力， 疗效显著， 值得临床推广应用。 　　【关键词】 脑出血保守治疗;神经保护治疗;单唾液酸四己糖神经节苷脂;依达拉奉 　　DOI：10.14163/j.cnki.11-5547/r.2015.04.004 　　Curative effect observation of monosialotetrahexosyl ganglioside combined with edaravone in conservative treatment of cerebral hemorrhage patients SUN Jun-ying. Shandong Province Jigang General Hospital， Jinan 250101， China 　　【Abstract】 Objective To observe the clinical effect of monosialotetrahexosyl ganglioside （Bosijie） combined with edaravone in conservative treatment of cerebral hemorrhage patients. Methods A total of 100 patients with cerebral hemorrhage by conservative treatment were divided into observation group and control group with 50 cases in each group， by random number table method. The control group received neuroprotective agent Bosijie， adding to the conventional treatment. The observation group received additional edaravone in the basis of the control group. The treatment lasted for 14 d in both groups. Observations were made on the changes of national institutes of health stroke scale （NIHSS score）， activities of daily living index （Barthel index）， and serum high-sensitivity C-reactive protein （hs-CRP） in the two groups. The clinical effects were evaluated. Results Before the treatment， the differences of NIHSS score， Barthel index and serum hs-CRP had no statistical significance between the two groups （Pgt;0.05）. After the treatment， there were obvious improvements in NIHSS score， Barthel index and serum hs-CRP of the two groups. The