围生期孕产妇感染或定植B族链球菌耐药情况及基因型研究.docVIP

围生期孕产妇感染或定植B族链球菌耐药情况及基因型研究 　　[摘要] 目的 对围生期孕产妇感染或定植的B族链球菌的耐药情况及基因型进行研究，为临床治疗提供科学依据。方法 在2015年1月～2016年12月期间，选取780例围生期孕妇生殖道分泌物，运用GBS培养鉴定和药敏试验，统计分析其结果。 结果 780例孕妇的GBS携带者共检出245例，带菌率达到31.4%。低于30岁组的带菌率为28.6%，同30岁以上（包括30岁）的带菌率40.5%对比，差异有统计学意义（χ2=20.124，P0.05）。D-抑菌圈试验阳性率23.9%；万古霉素和利奈唑胺的耐药率为0%，青霉素为0.7%，氨苄西林为3.2%，头孢曲松为6.7%，呋喃妥因为9.4%，左氧氟沙星为21.9%，克林霉素为23.7%，红霉素为29.9%，四环素为58.2%。 结论 该区围生期孕产妇生殖道的GBS带菌率较高，感染率最高的是高龄孕妇；同时，围生期孕妇感染GBS对万古霉素、头孢曲松、青霉素、呋喃妥因和氨苄西林的敏感率较高。 　　[关键词] B族链球菌；围生期；带菌率；孕妇；药敏试验 　　[中图分类号] R714.7 [文献标识码] A [文章编号] 1673-9701（2017）18-0012-04 　　Resistance and genotype of B streptococcus infected or colonized in perinatal pregnant woman 　　WU Junlan QIAN Bixia 　　Department of Breast Surgery， Lishui City Maternal and Child Health Hospital in Zhejiang Province， Lishui 323000， China 　　[Abstract] Objective To analyze the infection and drug resistance of B group streptococcus（GBS） in perinatal pregnant women， as a basis for clinicians to develop effective prevention and treatment measures. Methods The reproductive tract secretions of 780 perinatal pregnant women from January 2015 to December 2016 were examined by GBS culture and susceptibility testing， and the results were analyzed statistically. Results A total of 245 GBS carriers were detected in 780 pregnant women， and the carrier rate was 31.4%.The carrier rate of the below 30-year-old group was 28.6%， and the difference was statistically significant compared with 40.5% of the more than 30 years old group（including 30 years old） （χ2=20.124， P0.05）. The resistance rate of vancomycin and linezolid was 0%. And the resistant rates of penicillin， ampicillin， ceftriaxone， nitrofurantoin， levofloxacin， clindamycin， erythromycin and tetracycline were 0.7%， 3.2%， 6.7%， 9.4%， 21.9%， 23.7%， 29.9% and 58.2% respectively. The positive rate of D-inhibition zone test was 23.9%. Conclusion GBS carrier rate of pregnant women in this area is high， and older women are more susceptible to infection. The sensitivity of perinatal pregnant women