国产BuMA支架在无保护左主干病变中应用研究.docVIP

国产BuMA支架在无保护左主干病变中应用研究 　　摘要：目的比较国产 BuMA 支架和进口 Xience Ⅴ支架在无保护左主干病变应用的有效性和安全性。方法回顾性分析81例无保护左主干病变置入BuMA支架（36例）或Xience V支架（45例）的患者，随访1年，观察冠状动脉造影及血管内超声情况，比较死亡、心肌梗死、靶病变重建等主要心血管事件及支架内再狭窄发生率。结果两组患者主要心血管事件的发生率差异无统计学意义（5.6% vs 6.7%，P=1.00）。两组患者支架内再狭窄的发生率差异无统计学意义（5.6% vs 6.7%，P=1.00）。两组患者支架内径的晚期丢失及支架内面积的晚期丢失差异无统计学意义(P=0.614，P=0.833)。结论在血管内超声的指导下，国产 BuMA 支架在无保护左主干病变中的应用拥有与Xience V支架相似的安全性及近中期疗效。 　　关键词：冠状动脉疾病；BuMA支架；血管成形术；左主干病变 　　中图分类号：R815文献标识码：Bdoi:10.3969/j.issn2014.06.010文章编号2014 　　 　　Application of Domestic BuMA Drugeluting Stent in Patients with Unprotected Left Main Coronary Artery Disease 　　Zuo Huihua,Liu Qiang,Weng Jianxin,et al 　　Department of Cardiology,Shenzhen Sun Yatsen Cardiovascular Hospital (Shenzhen 518020） 　　Abstract:Objective To compare the efficacy and safety of domestic BuMA stent with Xience Ⅴ stent for treatment of unprotected left main coronary artery (ULMCA) disease.MethodsEightyone patients with symptomatic coronary artery disease undergoing percutaneous coronary intervention for uLMCA lesions were assigned to BuMA stent group (n=36) or Xience V stent group (n=45).The incidence of death,myocardial infarction,and target lesion revascularization at 1 year was observed and the Results measured by coronary angiography and intravascular unltrasound were analyzed.ResultsThere was no significantly differences in incidence of death,myocardial infarction,and target lesion revascularization at 1 year in both groups (5.6% vs 6.7%，P=1.00).Angiographic restenosis was 5.6% in BuMA group and 6.7% in Xience V group (P=1.00).There were no significantly differences in late lumen loss and the late area loss in two groups (P=0.614，P=0.833).ConclusionUnder the guidance of intravascular ultrasound,BuMA as Xience stent was safety and efficiency for uLMCA lesions. 　　Key words:coronary artery disease;BuMA stent;angioplasty;left main coronary artery 　　 　　左冠脉主干根源于升主动脉之左侧冠状动脉窦，是左冠状动脉的起源，左主干及其分支为左心室提供了80%的血供。左主干病变(left main coronary atery，L