基金项目安徽省高等学校自然科学基金（编号KJ2015B.docVIP

基金项目：安徽省高等学校自然科学基金（编号：KJ2015B097by) 斑蝥酸钠维生素B6注射液对青年乳腺癌术后化疗患者的影响 周锐 董慧明 黄建康 陈春春 彭德峰 朱金海 朱正志 崔振 王岩岩 蚌埠医学院第一附属医院，蚌埠233000 【摘要】目的 观察斑蝥酸钠维生素B6注射液联合化疗对青年乳腺癌术后化疗患者的临床效果。方法 将87例患者按照随机数字表法随机分为2 组，分别为对照组( n = 42) 和观察组( n = 45) 。观察组在对照组基础上联合斑蝥酸钠维生素B6注射液治疗。对比分析两组治疗前后血常规、肝肾功能、心电图、T 细胞亚群、自然杀伤（NK）细胞情况。结果 经治疗后，观察组的白细胞及血小板计数下降、肝功能异常患者所占比例均低于对照组，T 细胞亚群及NK 细胞占比高于对照组，差异均有统计学意义（P0.05）。两组患者中肾功能及心电图异常差异无统计学意义。结论 斑蝥酸钠维生素B6注射液联合化疗治疗青年乳腺癌术后化疗患者，可以降低骨髓抑制发生率，改善肝功能，提高患者的免疫功能。 【关键词】斑蝥酸钠维生素B6；乳腺肿瘤；免疫功能；化疗 Effect of Cantharis acid sodium vitamin B6 injection on youth postoperative chemotherapy patients with Breast cancer Zhou Rui,Dong Huiming,Huang Jiankang,Chen Chunchun,Peng Defeng,Zhu Jinhai,Zhu Zhengzhi,Cui Zhen,Wang Yanyan The First Affiliated Hospital of Bengbu Medical College,Bengbu 233000 【Abstract】Objective To observe the clinical effect of cantharis acid sodium vitamin B6 injection combined with chemotherapy on youth postoperative patients with breast cancer.Methods 87 patients were randomly divided into the control group (n = 42) and observation group (n = 45) according to random number table method. The observation group received cantharis acid sodium vitamin B6 injection on the basis of the control group．Comparison of the blood routine, liver and kidney function, electrocardiogram (ecg), T cell subsets and natural killer (NK) cells of the two groups before and after treatment were analyzed.Results After treatment, the observation group of the? proportion of patients with decreasing of blood cell and platelet count and abnormal liver function were lower than the control group, T cell subsets and NK cells proportion is higher than the control group, the differences were statistically significant (P0.05).The abnormal ecg and renal function between the two groups have no statistical significance.Conclusion Clinical observation of Cantharis acid sodium vitamin B6 injection combined with chemotherapy on youth postoperative patients with breast cancer , can reduce the inc