孕妇抗磷脂抗体胰岛素样生长因子I与胎儿生长受限相关性研究.docVIP

孕妇抗磷脂抗体胰岛素样生长因子I与胎儿生长受限相关性研究 　　[摘要] 目的 探讨胎儿生长受限（FGR）孕妇抗心磷脂抗体（ACA）与胎盘组织胰岛素样生长因子- I（IGF-I）表达水平间的关系及两者在FGR发生中的作用。 方法 采用酶联免疫吸附法（ELISA法）测定63例正常足月妊娠孕妇（对照组）及63例胎儿生长受限孕妇(研究组)血清中ACA-IgG、IgM；利用免疫组织化学方法及多媒体彩色病理图像分析技术测定胎盘组织IGF-I表达水平。 结果 研究组抗心磷脂抗体阳性率为19.0%，对照组为3.2%，两组比较，有显著性差异（P＜0.05）; 研究组胎盘组织IGF - 1表达水平明显低于对照组（P＜0.05） ；ACA阳性组与ACA阴性组两组比较，胎盘组织IGF-I表达水平无显著差异（P＞0.05），胎盘重量、胎儿体重有显著差异（P＜0.05）。 结论 孕妇血清ACA阳性或胎盘组织IGF-I表达水平下降是导致FGR的危险因素之一，ACA是否也会导致胎盘组织IGF-I表达水平下降有待进一步研究。 　　[关键词]胎儿生长受限；胰岛素样生长因子Ⅰ；抗心磷脂抗体 　　[中图分类号] R714.5#8195;#8195;#8195;[文献标识码] A#8195;#8195;#8195;[文章编号] 2095-0616（2014）08-13-03 　　 　　Correlation study of pregnant womens antiphospholipid antibody and insulin-like growth factor I and fetal growth restriction 　　BAN#8195;Zhenghe1#8195;#8195;LI#8195;Lichang1#8195;#8195;WENG#8195;Biyan2 　　1.Guangzhou Baiyun District First Peoples Hospital,Guangzhou 510410,China;2.Guangzhou Baiyun District Red Cross Hospital,Guangzhou 510545,China 　　[Abstract] Objective To investigate the relationship between the pregnant womens expression levels of anti-cardiolipin antibody (ACA) and placental tissue insulin-like growth factor-1 (IGF-I)and their role in fetal growth restriction (FGR). Methods The enzyme-linked immunosorbent assay (ELISA) was used to detect the serum ACA-IgG and IgM of 63 pregnant women with normal full-term pregnancy (control group)and 63 patients with fetal growth restriction(study group);The immunohistochemical method and multimedia color pathological image analysis technique were used to measure the IGF-I expression level in placenta tissues. Results The positive rate of ACA in the study group was 19.0% and that in the control group was 3.2%,with significant difference between the two groups(P＜0.05);The study group was significantly lower than the control group in the IGF-I expression level in placenta tissues(P＜0.05); The ACA positive group and the ACA negative group were not significantly different in the IGF-I expression level in placenta tissues(P＞0.05),but were sig