SPIO标记细胞磁靶向移植修复关节软骨缺损可行性的初步分析-外科学(骨外)专业论文.docxVIP

第三军医大学硕士学位论文 第三军医大学硕士学位论文 PAGE PAGE 2 In vivo targeted magnetic delivery of superparamagnetic iron oxide particles labeled cells for articular cartilage defect repair Abstract Background： Articular cartilage defects is one of the common clinical diseases in skeletal motor system. As it’s known to all that cartilage repair is difficult that pain and joint dysfunction might be relieved but disease progression which will have bad influence on patients’ life could not be reversed by current drugs or other treatments. Various clinical methods have respective weaknesses. To our knowledge, no ideal treatment has been found to repair articular cartilage defect. As tissue engineering and regenerative medicine develop rapidly, many attention has been focused on the cell transplantation which has been considered as one of the effective treatments in carliage repair. And intra-articular injection might be one of the easiest and the least invasive procedures in cell- based therapy in this area. It has been reported that MSCs-based cell therapy through intra-articular injection could repair the cartilage defect in experimental studies, but problems with the injection of isolated cells is that the seed cells have to travel a long distance from the entry site to the injury area, where they probably cannot reside in the desired area because of lack of specific homing. Moreover, a large number of transplanted seed cells might be diluted by the joint fluid and adhere other tissues anywhere in the joint cavity. Then the risk of potential complications such as synovitis, Synovial hyperplasia, or free bodies of scar tissue will increase, and only a small portion of the cells adhere to the cartilage defects that the therapeutic efficacy is not as good as we expect. Therefore, how to balance the trauma and efficiency during our treatment is a real challenge all the time. And this emerging technology of cell transplantation by intra-articular injection needs to be improved. Any