沙丁胺醇联合布地奈德治疗小儿哮喘急性发作效果评价.docVIP

沙丁胺醇联合布地奈德治疗小儿哮喘急性发作效果评价 　　【摘要】 目的 探讨沙丁胺醇联合布地奈德治疗小儿哮喘急性发作的效果。方法 100例哮喘急性发作患儿， 随机分为对照组和观察组， 各50例。对照组采用氨茶碱进行治疗， 观察组采用沙丁胺醇联合布地奈德治疗。比较两组临床效果。结果 观察组患儿肺部??音消失时间、气促消失时间、喘憋消失时 　　间、咳嗽消失时间分别为（5.41±1.38）、（2.48±0.29）、（2.74±1.53）、（6.38±1.52）d， 均短于对照组的（7.93±1.61）、（3.82±1.49）、（3.54±1.85）、（8.56±1.54）d， 差异有统计学意义（P0.05）。治疗后， 两组最大呼气流速（PEFR）、第一秒用力呼气量（FEV1）、用力肺活量（FVC）水平均优于治疗前， 且观察组明显优于对照组， 差异有统计学意义（P0.05）。结论 沙丁胺醇联合布地奈德治疗具有疗效高、安全性高、操作简单等优势， 用于哮喘急性发作患儿中， 能够加快临床症状的改善。 　　【关键词】 沙丁胺醇；布地奈德；哮喘急性发作；效果 　　DOI：10.14163/j.cnki.11-5547/r.2018.05.049 　　【Abstract】 Objective To discuss the effect of salbutamol combined with budesonide in the treatment of acute attack of asthma in children. Methods A total of 100 children with acute attack of asthma were randomly divided into control group and observation group， with 50 cases in each group. The control group was treated with aminophylline， and the observation group was treated with salbutamol combined with budesonide. The clinical effect in two groups was compared. Results The observation group had pulmonary rales disappearance time， shortness of breath disappearance time， wheezing disappearance time， cough disappearance time respectively as （5.41±1.38）， （2.48±0.29）， （2.74±1.53） and （6.38±1.52） d， which were all shorter than （7.93±1.61）， （3.82±1.49）， （3.54±1.85） and （8.56±1.54） d in the control group， and their difference was statistically significant （P0.05）. After treatment， both groups had better peak expiratory flow rate （PEFR）， first second forced expiratory volume （FEV1） and forced vital capacity （FVC） than before treatment， and the observation group was obviously better than the control group. Their difference was statistically significant （P0.05）. Conclusion Combination of salbutamol and budesonide has the advantages of high efficacy， high safety and simple operation. It can accelerate the improvement of clinical symptoms in children with acute asthma. 　　【Key words】 Salbutamol； Budesonide； Acute attack of asthma； Effect 　　哮喘急性发作患儿主要表现为胸闷、