泛耐药鲍曼不动杆菌所致呼吸机相关性肺炎应用替加环素治疗临床疗效.docVIP

泛耐药鲍曼不动杆菌所致呼吸机相关性肺炎应用替加环素治疗临床疗效 　　[摘要] 目的 探讨替加环素治疗泛耐药鲍曼不动杆菌所致呼吸机相关性肺炎的临床疗效。 方法 选择2014年1月～2016年12月在我院住院发生耐药鲍曼不动杆菌呼吸机相关肺炎患者60例的临床资料进行回顾性分析。其中30例患者采用美罗培南治疗为对照组，30例患者采用替加环素治疗为研究组。比较两组临床疗效，细菌清除率，出院1个月病死率。 结果 研究组总有效率为70%，显著高于对照组，差异有统计学意义（P0.05）。研究组用药疗程较对照组时间长，细菌清除率为70%，显著高于对照组，出院1个月病死率为46.7%，显著低于对照组，差异有统计学意义（P0.05）。 结论 替加环素治疗泛耐药鲍曼不动杆菌所致呼吸机相关性肺炎能够提高细菌清除率以及临床疗效，改善患者预后。 　　[关键词] 替加环素；耐药鲍曼不动杆菌；呼吸机相关性肺炎 　　[中图分类号] R563.1 [文献标识码] A [文章编号] 2095-0616（2017）10-22-04 　　Clinical efficacy of tigecycline for ventilator associated pneumonia with pan-drug resistant acinetobacter Bauman 　　WEI Wei1 LI Long1 WU Xiaomeng1 YUAN Xiumei2 　　1.Pharmacy Department， the Second Affiliated Hospital of Mudanjiang Medical University， Heilongjiang， Mudanjiang 157000， China； 2. The First Ward of Internal Medicine-Neurology， Hongqi Hospital Affiliated to Mudanjiang Medical University， Heilongjiang， Mudanjiang 157000， China 　　[Abstract] Objective To discuss the clinical efficacy of Tigecycline for Ventilator associated pneumonia with pan-drug resistant Acinetobacter Bauman. Methods Clinical data of 60 cases with Ventilator associated pneumonia with pan-drug resistant Acinetobacter Bauman from Jan 2014 to Dec 2016 were retrospectively analyzed. 30 cases treated with Meropenem were control group， and 30 cases treated with Tigecycline were study group. Clincal efficacy and bacterial clearance， mortality rate after one month of discharge of two groups were compared. Results Total effective rate of study group was 70%， which was higher than that of control group， and the difference was statistically significant（P0.05）. Medication course of study group was longer than that of control group（P0.05）. Bacterial clearance rate of study group was 70%， which was higher than that of control group， and the difference was statistically significant（P0.05）. Mortality rate after one month of discharge of study group was 46.7%， which was lower than that of control group， and the difference was statistically significant（