β-谷甾醇降低阿司匹林副作用及对其药理作用影响的实验研究-药理学专业论文.docxVIP

万方数据 万方数据 目 录 中文摘要······························································································· (1) 英文摘要······························································································· (2) 论文题目······························································································· (3) 前言····································································································· (3) 1 实验材料·························································································· (3) 2 方法································································································ (4) 3 结果································································································ （6） 4 讨论································································································· （10） 参考文献····························································································· （11） 文献综述····························································································· （12） 参考文献····························································································· （17） 缩略语表····························································································· （20） 攻读学位期间发表文章情况····································································· （21） 个人简历····························································································· （22） 致谢··································································································· （23） 内蒙古医科大学硕士研究生学位论文 内蒙古医科大学硕士研究生学位论文（2015） 1 中文摘要 目的：探讨?-谷甾醇能否减弱阿司匹林的胃粘膜损伤作用，并同时观察其对阿司匹林药理作 用的影响，为研制具有较低副作用的阿司匹林复方制剂提供新的思路。方法：成功复制阿司 匹林介导的大鼠胃黏膜损伤模型，灌胃给予不同剂量的?-谷甾醇（50、150、250 mg·kg-1）， 以溃疡面积为评价指标，摸索?-谷甾醇减轻阿司匹林导致胃粘膜损伤的最佳有效剂量；分别 复制发热模型，热板、扭体疼痛模型，耳肿胀、足趾肿胀炎症模型，观察灌胃给予不同剂量 的?-谷甾醇是否影响阿司匹林药理作用。结果：β-谷甾醇可降低阿司匹林诱导的胃粘膜损 伤；不同剂量的β-谷甾醇、奥美拉唑组与阿司匹林、空白组相比，大鼠机体 SOD、NO、MDA、 TNF-a 含量差异具有显著性（P﹤0.05），PGE2 含量无显著性差异（P﹥0.05）；通过发热模型、 热板、扭体、血小板聚集率等证实，不同剂量的