法舒地尔对急性脑梗死患者血清CRPHcy水平变化多中心研究.docVIP

法舒地尔对急性脑梗死患者血清CRPHcy水平变化多中心研究 　　【摘要】 目的：通过多中心研究来探究法舒地尔对急性脑梗死患者血清C反应蛋白、同型半胱氨酸水平变化的影响。方法：选取A院、B院、C院神经内科收治的急性脑梗死患者共96例，采用随机数字表法将其分为试验组和对照组各48例。其中对照组给予常规治疗，试验组在常规治疗的基础上加用静脉点滴盐酸法舒地尔30 mg/次，2次/d，连续两周。观察比较两组患者治疗前后的血清中Hcy、CRP水平。结果：两组治疗后的血清中Hcy、CRP水平均明显低于治疗前，且试验组血清中Hcy、CRP水平均明显低于对照组，差异均有统计学意义（P0.05）。结论：盐酸法舒地尔能够明显改善急性脑梗死患者血清中CRP水平和Hcy水平，改善患者的神经功能缺损，对临床具有指导意义，值得临床推广。 　　【关键词】 法舒地尔； 急性脑梗死； CRP水平； Hcy水平； 多中心研究 　　中图分类号 R743.33 文献标识码 A 文章编号 1674-6805（2014）35-0007-02 　　【Abstract】 Objective：To explore the effects of Fasudil on the serum level of CRP and Hcy in acute cerebral infarction patients through the multicenter study.Method：96 patients with acute cerebral infarction admitted in neurology of A，B，C hospital were selected，and they were divided into the experimental group and the control group according to the random number table method，48 cases in each group.The control group was treated with routine therapy.The experimental group was treated with intravenous drip of Fasudil hydrochloride 30 mg once a time on the basis of routine therapy，twice daily，lasted for two weeks.The serum level of CRP and Hcy between the two groups before and after treatment were observed and compared.Result：The serum Hcy，CRP levels of two groups after treatment were significantly lower than before treatment，and the serum Hcy，CRP levels in experimental group were significantly lower than those in control group，the differences were statistically significant（P0.05）.Conclusion：The Fasudil can obviously improve the serum level of CRP and Hcy in the patients with acute cerebral infarction，improve the patients’ neurologic deficits，and has the guidance significance for clinical，is worth the clinical promotion. 　　【Key words】 Fasudil； Acute cerebral infarction； CRP level； Hcy level； Multicenter study 　　急性脑梗死（ACI）又名急性缺血性脑卒中，指由于脑部血供异常，引起局灶性脑组织的缺血、缺氧，进而导致脑组织软化和局部缺血性坏死[1]。据调查统计，我国每年新发现的脑卒中患者在150万以上，该疾病的发病率尚有逐年上升的趋势。因此，国内外许多专家和学者进行了大量的研究。研究发现，盐酸法舒地尔可通过抑制Rho激酶，来改善急性脑梗死患者脑部血供，起到一定的治疗作用[2]。为了进一步探究盐酸法舒地尔对于急性脑梗死的临床疗效