沙丁胺醇治疗小儿哮喘性支气管炎疗效及作用机制研究.docVIP

沙丁胺醇治疗小儿哮喘性支气管炎疗效及作用机制研究 　　[摘要] 目的 探究沙丁胺醇治疗小儿哮喘性支气管炎的疗效及作用机制。方法 方便选取2016年7月―2017年7月该院哮喘性支气管炎患儿82例，采用随机数表法分组，各41例。对照组予以常规治疗，观察组在对照组基础上予以沙丁胺醇治疗。对比两组临床疗效及不良反应发生情况，对比两组肺??音消失时间、气喘消失时间、咳嗽消失时间。 结果观察组治疗总有效率90.24%（37/41）较对照组73.17%（30/41）高，差异有统计学意义（P0.05）。 结论 沙丁胺醇治疗小儿哮喘性支气管炎，可增强治疗效果，缩短患儿恢复时间，降低不良反应发生率，值得临床临床推广。 　　[关键词] 沙丁胺醇；哮喘性支气管炎；疗效；作用机制 　　[中图分类号] R272 [文献标识码] A [文章编号] 1674-0742（2017）11（c）-0112-03 　　[Abstract] Objective This paper tries to explore the efficacy and mechanism of salbutamol in the treatment of asthmatic bronchitis in children. Methods 82 cases of children with asthma bronchitis in this hospital from July 2016 to July 2017 were convenient selected and divided into two groups， with 41 cases in each group， according to the random number table method. The control group was treated with routine therapy， and the observation group was treated with salbutamol on the basis of the control group. The clinical efficacy and adverse reactions of the two groups were compared， and the rales disappearance time， the asthma disappearance time and the cough disappearance time were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group [90.24%（37/41） vs 73.17% （30/41）] （P0.05）. Conclusion Salbutamol for children with asthmatic bronchitis can enhance the treatment effect， shorten the recovery time and reduce the incidence rate of adverse reactions， therefore it is worthy of clinical promotion. 　　[Key words] Salbutamol； Asthmatic bronchitis； Efficacy； Mechanism 　　哮喘性支?夤苎孜?儿科呼吸系统疾病指多种细胞参与的气道炎症。随着环境污染加重，小儿哮喘性支气管炎发病率明显升高。小儿气管、支气管、毛细支气管狭窄，发育不完善，易受到微生物感染，气管粘膜发生肿胀或充血，支气管出现痉挛。哮喘性支气管炎主要症状有喘息、胸闷、气促、咳嗽、呼吸困难，影响患儿正常生活，严重者可出现生命危险。临床常采用地塞米松及异丙托溴铵治疗哮喘性支气管炎，地塞米松属于糖皮质激素类药物，具有抗炎、抗病毒作用，可减轻患儿炎症反应；异丙托溴铵为强效抗胆碱药，可舒张支气管平滑肌，缓解患者咳嗽、喘息等症状，但二者治疗哮喘性支气管炎均未能达到理想效果。β2受体激动剂在临床应用较广，急性期患者可选用速效β2受体激动剂沙丁胺醇雾化吸入治疗，沙丁胺醇可抑制致过敏物释放，减轻支气管痉挛。熊银梅等[1]研究发现，沙丁胺醇雾化吸入治疗急性期毛细支气管炎患者，可缓解患者临床症状，提高治疗效果。该研究方便选取2016年7月―2017年7月该院哮喘性支气管炎患儿82例，分组探究沙丁胺醇治疗小儿哮喘