帕罗西汀联合奥氮平治疗抑郁症临床观察.docVIP

帕罗西汀联合奥氮平治疗抑郁症临床观察 　　[摘要] 目的 探讨帕罗西汀联合奥氮平治疗抑郁症的临床疗效。 方法 随机选取我院收治的抑郁症患者100例，随机分成观察组50例，对照组50例。对照组患者给予盐酸帕罗西汀片口服治疗，观察组患者在对照组的基础上给予奥氮平片口服治疗，6个月后比较两组患者的总有效率，采用汉密尔顿抑郁量表（HAMD）、匹兹堡睡眠质量指数（PSQI）及副反应量表（TESS）对两组患者的治疗第1、3、6个月的抑郁、睡眠程度及不良反应情况进行观察评价。 结果 6个月后观察组患者的总有效率明显高于对照组；经1、3、6个月治疗后，观察组患者的HAMD及PSQI明显降低，TESS无明显差异。 结论 帕罗西汀联合奥氮平治疗抑郁症可明显减轻患者抑郁，缓解睡眠，副反应少，值得临床推广。 　　[关键词] 帕罗西汀；奥氮平；抑郁症；汉密尔顿抑郁量表；匹兹堡睡眠质量指数；副反应量表 　　[中图分类号] R749.4 [文献标识码] B [文章编号] 1673-9701（2016）14-0106-03 　　[Abstract] Objective To explore the clinical curative effects of paroxetine combined with olanzapine in the treatment of depression. Methods 100 patients with depression who were admitted to our hospital were randomly selected. They were randomly assigned to the observation group with 50 patients and the control group with 50 patients. The control group was orally given paroxetine hydrochloride， and the observation group was orally given olanzapine on the basis of the control group. The total effective rate after 6 months was compared between the two groups. Patients depression degree， sleeping condition and adverse reactions were observed and evaluated by HAMD， PSQI and TESS at the first， third and sixth months after the treatment in both groups. Results The total effective rate in the observation group after 6 months was significantly higher than that in the control group. After the treatment for 1， 3 and 6 months， HAMD and PSQI in the observation group were both significantly reduced， but TESS was not significantly different. Conclusion Paroxetine combined with olanzapine in the treatment of depression is able to significantly reduce patients depression， improve sleeping and have less adverse reactions， which is worthy of clinical promotion. 　　[Key words] Paroxetine； Olanzapine； Depression； Hamiltons depression scale； Pittsburgh sleep quality index； Treatment emergent symptom scale 　　抑郁症是由多种因素引发的以情绪低落为主要表现的心理障碍，是全球第二大类负担疾病[1]。该病严重影响患者的身体及心理健康，给社会和家庭带来很大的负担，严重者甚至有自杀倾向。抑郁症患者往往出现睡眠障碍，有资料显示[1，2]，有60%的抑郁症患者的睡眠时间减少及