幽门螺杆菌感染对血脂代谢影响.docVIP

幽门螺杆菌感染对血脂代谢影响 　　【关键词】 幽门螺杆菌;血脂代谢;胃肠道疾病 　　中图分类号：R589.2 文献标识码：A DOI：10.3969/j.issn.1003-1383.2018.01.018 　　Effect of Helicobacter pylori infection on blood lipid metabolism 　　CHEN Fang，WEN Jin，DONG Yunqi 　　【Abstract】 Objective To investigate the effect of Helicobacter pylori （HP） infection on blood lipid metabolism in healthy physical examination people. 　　Methods A total of 2035 healthy persons who underwent HP and blood lipid tests from August，2015 to May，2017 were collected.All the subjects were tested for HP and blood lipid indexes （including TC，TG，HDL-C and LDL-C）.And relationship between HP infection and blood lipid metabolism was observed. 　　Results Among 2035 people，the positive rate of HP was 38.0%，the positive rate of HP in males was 42.9%，which was higher than that（35.4%） in females，difference was statistically significant（Plt;0.001）.In HP positive people，HDL-C level was （1.37±0.03）mmol/L，which was lower than that（1.41±0.02）mmol/L in HP negative people，and LDL-C level was （3.13±0.04）mmol/L，higher than that（3.08±0.05）mmol/L in HP negative people，difference was statistically significant（Plt;0.001）.The proportion of decrease of HDL-C and increase of LDL-C in HP positive people was 18.6% and 34.1%，respectively，higher than that in HP negative people which was 15.1% and 29.3%，respectively，difference was statistically significant（Plt;0.05）.There was no significant difference in the TC and TG levels，and the proportion of increase of TC and TG between the HP positive people and the HP negative people（Pgt;0.05）. 　　Conclusion The incidence of HP infection in male with healthy physical examination is higher，and it is related to abnormal metabolism of blood lipids，especially with the decrease of HDL-C and the increase of LDL-C. 　　【Key words】 HP;blood lipid metabolism;gastrointestinal diseases 　　幽?T螺杆菌（HP）与消化道溃疡、慢性胃炎、胃黏膜相关淋巴组织淋巴瘤等胃部疾病密切相关[1]。有研究报道，HP是一种致癌物，它可诱发胃癌[2]。近期有研究发现，HP感染在心血管病变、动脉粥样硬化等疾病发生过程中发挥重要作用[3]。血脂异常是冠心病（coronary heart disease，CHD）的独立影响因素，其中