异甘草酸镁联合降脂治疗非酒精性脂肪型肝炎及对肝功能影响.docVIP

异甘草酸镁联合降脂治疗非酒精性脂肪型肝炎及对肝功能影响 　　[摘要] 目的 探析异甘草酸镁联合降脂治疗非酒精性脂肪型肝炎疗效及对肝功能影响。方法 以该院2011年5月―2014年10月期间所收治92例非酒精性脂肪型肝炎患者展开研究，对照组给予以调脂为主综合治疗，观察组加用异甘草酸镁，比较两组治疗前后PCⅢ、C-ⅠV、HA及ALT、AST、TBIL、γ-GT等肝纤维化指标。 结果 两组治疗前各肝纤维化指标的比较无统计学意义（P0.05）；治疗后，观察组PCⅢ、C-ⅠV、HA等指标均显著降低，与治疗前比较差异有统计学意义（P0.05），治疗后两组各指标的比较差异有统计学意义（P0.05）；组内比较上，两组治疗前后各指标的比较差异有统计学意义（P0.05）。结论 异甘草酸镁可保护肝细胞，与降脂治疗联合应用于NASH患者可有效抑制肝细胞纤维化，促进肝功能的恢复，应用价值高。 　　[关键词] 异甘草酸镁；降脂治疗；非酒精性脂肪型肝炎；肝功能 　　[中图分类号] R53 [文献标识码] A [文章编号] 1674-0742（2015）06（a）-0097-02 　　Magnesium Isoglycyrrhizinate Combined with Lipid-lowering Therapy for Nonalcoholic Fatty Hepatitis and Its Effect on Liver Function 　　LIU Tian-bao 　　Department of Gastroenterology， TCM Hospital of Jiyuan City， Jiyuan， Henan Province， 459000 China 　　[Abstract] Objective To probe into magnesium isoglycyrrhizinate combined with lipid-lowering efficacy in the treatment of non-alcoholic fatty hepatitis and its effect on liver function. Methods 92 patients with cases non-alcoholic fatty hepatitis in our hospital during May 2011-October 2014 were selected as the research object： control group was given lipid based comprehensive treatment， which the observation group received comprehensive treatment combined with magnesium isoglycyrrhizinate. PC III， C- I V， HA and ALT， AST， TBIL， -GT and other indexes of hepatic fibrosis gamma of two groups before and after treatment were compared. Results Two groups before treatment， difference of indexes of hepatic fibrosis had no statistical significance （P 0.05）； after the treatment， the index PC III， C- I V， HA etc of observation group were significantly lower， difference were statistical significance compared with before treatment （P 0.05）， after the treatment， differences between two groups were statistically significant （P 0.05）； within group comparison， the two groups before and after treatment of each index were statistically significant （P 0.05）. Conclusion Magnesium isoglycyrrhizinate， which can protect the liver cells， combined with lipid-l