手足口病患儿血清淋巴细胞免疫分型水平变化及临床意义.docVIP

手足口病患儿血清淋巴细胞免疫分型水平变化及临床意义 　　摘 要：目的 探讨手足口病患儿中血清淋巴细胞免疫分型水平变化，为诊断及治疗手足口病提供临床诊治意义。方法 选取四川省宜宾市第一人民医院2013年3月～2015年3月儿科手足口患儿 150例（分为重症组54例，轻症组96例）及行儿科保健健康儿童105例；采用流式细胞仪进行血清淋巴细胞免疫分型的水平检测，并行组间比较。结果 重症患儿血清淋巴细胞免疫分型水平较轻型低，轻型较健康儿童水平低，差异有统计学意义（P0.05）。结论 手足口病患儿免疫功能较正常健康儿童呈降低趋势，其中重症患儿免疫功能更低，分析血清淋巴免疫细胞分型水平可作为手足口病患儿判断疾病病情变化及临床治疗观察的一种方法。 　　关键词：手足口病；血清淋巴细胞免疫分型；T淋巴细胞 　　中图分类号：R725.1 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.01.029 　　文章编号：1006-1959（2018）01-0082-03 　　Serum Level of Lymphocyte Immunophenotype in Children with Hand-foot-mouth Disease and its Clinical Significance 　　REN Yan 　　（Department of Pediatrics，Fourth Peoples Hospital of Yibin，Yibin 644000，Sichuan，China） 　　Abstract：Objective To investigate the changes of serum immunocytotyping in children with hand foot and mouth disease and provide clinical diagnosis and treatment of hand foot and mouth disease.Methods From Yibin First Peoples Hospital of Sichuan Province in March 2013～March 2015 pediatric HFMD patients in 150 cases（54 cases in severe group and 96 cases in mild group）and 105 healthy children for pediatric care；The detection of serum lymphocyte immunophenotyping by flow cytometry，parallel comparison between groups.Results Serum levels of lymphocyte subsets in children with severe light level is low，low level light compared with healthy children，the difference was statistically significant（P0.05）.Conclusion The immune function of children with hand foot and mouth disease is lower than that of healthy children.The immune function of severe children is lower.The analysis of serum lymphoid immune cell typing level can be used as a way to diagnose the disease and to observe the clinical treatment of children with hand foot and mouth disease. 　　Key words：Hand foot and mouth disease；Serum lymphocyte immunophenotype；T lymphocyte 　　手足口病（hand foot and mouth disease，HFMD）作为丙类传染病，在学龄前期儿童发病率较高，尤其3岁儿童发病率最高，对儿童健康造成极大危害[1]，手足口病主要通过密切接触、呼吸道等途径进行传播，临床表?F为手、足、口腔黏膜可见皮疹（以斑疹、疱疹常见）以及发热等症状；儿童手足口病分为普通型及重症型；重症型手足口病患儿可出现肺水肿、心肌炎、呼吸循环衰竭