急诊腹膜透析对急性重症胰腺炎患者炎症细胞因子影响及治疗效果.docVIP

急诊腹膜透析对急性重症胰腺炎患者炎症细胞因子影响及治疗效果 　　[摘要] 目的：探讨腹膜透析对急性重症胰腺炎患者血浆炎症细胞因子的影响。方法：选择我院2008年3月~2010年12月急诊收治的急性重症胰腺炎患者60例，随机分为腹透组（30例）和常规组（30例），腹透组患者给予腹膜透析治疗，常规组患者给予胃肠减压、抗炎症、抑酶等常规治疗，观察两组患者症状缓解情况、治疗效果及治疗前后血浆炎症细胞因子变化情况。结果：治疗后腹透组患者腹痛、腹胀缓解时间短于常规组，治愈率高于常规组，并发症发生率低于常规组，两组比较差异有统计学意义（P0.05或P0.01）；两组治疗3、7 d后白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）均较治疗前降低，治疗前后比较差异均有统计学意义（均P0.05），腹透组患者治疗3、7 d后IL-6、IL-8、TNF-α、CRP均明显低于常规组，两组比较，差异均有统计学意义（均P0.05）。结论：腹膜透析早期治疗急性重症胰腺炎可纠正炎症细胞因子的释放，降低血浆炎症细胞因子的含量，可较好地缓解症状，治愈率高，并发症少，有较高的临床应用价值。 　　[关键词] 急性重症胰腺炎；腹膜透析；炎症细胞因子；临床分析 　　[中图分类号] R576 [文献标识码] Ａ [文章编号] 1673-7210（2011）12（b）-063-03 　　 　　Effects analysis of peritoneal dialysis on inflammatory cytokine in severe acute pancreatitis 　　WANG Hongsheng 　　BenQ Medical Centre in Nanjing City (Nanjing Medical University Affiliated Hospital), Jiangsu Province, Nanjing 210019, China 　　[Abstract] Objective: To explore the effects of peritoneal dialysis on inflammatory cytokines in severe acute pancreatitis patients. Methods: 60 severe acute pancreatitis patients in our hospital from March 2008 to December 2010 were randomly divided into PD group (30 cases) and conventional group (30 cases), PD group was treated with peritoneal dialysis, conventional group was treated with decompression, anti-inflammatory, inhibiting enzymes and other conventional treatment, symptoms relief, treatment effect and inflammatory cytokines changes before and after treatment were observed. Results: After treatment, abdominal pain, abdominal bloating relief time of PD group were significantly shorter than those of the conventional group, the cure rate was significantly higher than that of the conventional group, the complication rate was significantly lower than that of conventional group, the differences were statistically significant (P0.05 or P0.01); IL-6, IL-8, TNF-α, CRP of two groups all significantly decreased 3 and 7 days after treatment (all P0.05), and IL-6, IL-8, TNF- α, CRP of PD group 3, 7 days after treatment were