潮汕贲门癌中p-erk蛋白表达与幽门螺杆菌感染的相关性研究-relationship between the expression of p - erk protein and helicobacter pylori infection in chaoshan cardia cancer.docxVIP
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潮汕贲门癌中p-erk蛋白表达与幽门螺杆菌感染的相关性研究-relationship between the expression of p - erk protein and helicobacter pylori infection in chaoshan cardia cancer
汕头
汕头 大学医 学院 硕士研 究生学 位论 文
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PAGE III
感染与CD74蛋白的平均光密度的相关系数rs为0.539(p0.01);CD74蛋白的平均光密度与
p-ERK 蛋白阳性标记指数的相关系数rs 为0.334(p0.01),结果有高度统计学意义。SIMPLE 同部位标记和消除抗体法进一步验证了三者在肿瘤局部区域存在共表达。
结论
1.p-ERK 蛋白在贲门癌组织中表达明显高于其对应的正常粘膜和癌旁粘膜组织,提示 p-ERK 蛋白在贲门癌发生发展过程中起一定作用;且低分化贲门癌中 p-ERK 表达最高,提示 p-ERK 蛋白表达差异还与肿瘤细胞分化程度相关。
2. p-ERK 蛋白表达与 H.pylori 定植密度成正相关,提示 H.pylori 定植可能影响与激活 p-ERK 蛋白表达。
3.p-ERK、CD74 蛋白表达水平和 H.pylori 定植密度三者互成正相关,提示 H.pylori 可通 过其受体 CD74 高表达参与 ERK 通路的激活。
4. 采用 SIMPL E 同部位标记和消除抗体法验证发现贲门癌中 H.pylori 与 p-ERK 蛋白、CD74 与 p-ERK 蛋白之间存在局部共表达,进一步提示 H.pylori 感染后可能通过 H.pylori-CD74- ERK 通路的激活,对贲门癌的发展发挥一定的作用。
【关键词】 贲门癌 p-ERK H.pylori CD74
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Abstract
Background and objective
Gastric Cardia Carcinoma(GCC) is a high incidence of malignant tumors in Chaoshan, the incidence of GCC was 34.81/10,000 , second only to esophageal cancer (EC).Helicobacter pylori infection was always found in Gastric Cardia Carcinoma(GCC), it planted in epithelial cells by flagella or taking CD74 as a receptor and injected CagA into cells to activate kinds of signal pat-
hways inducing proliferation, differentiation and apoptosis. Extracellular signal-regulated kinase (ERK) is the member of mitogen-activated protein kinase super family(M APK) and is one of the most important and classical pathways which was closely related to differentiation, tumorigensi- s, malignant degree,et al. However we still know little about the distribution and function of H. pylori in GCC. Our laboratory has detected distribution of H. pylori in Gastric Cardia Cancer in ChaoShan by reform ed Giemsa stain and immunohistochemistry stain. On this basis, this expe- riment combined immunohistochemistry of p-ERK protein and SIM PLE technology to observe and analyse the expression of p-ERK in normal mucosa, adjacent nontumorous mucosa and GCC tissue as well as the relationship between distribution of H. pylori and CD74 expression, to inve- stigate the correlation of distribution of H. pylori and p-ERK expression, and disc
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