性激素水平对老年人高血压病肾气亏虚证证型诊断客观化影响研究.docVIP

性激素水平对老年人高血压病肾气亏虚证证型诊断客观化影响研究 　　摘要：目的 探讨性激素平衡紊乱与老年人高血压病肾气亏虚证发病的相关性，为老年人高血压病肾气亏虚证证型诊断客观化的研究提供依据。方法 收集年龄65岁～75岁患有1级、2级高血压病，并符合肾气亏虚证或肝火上炎症辨证标准患者，每组40例；选择理化检查均正常的健康老年人作为正常对照组，男性20例，女性20例。对以上3组人群进行对照研究，采用放射免疫分析法比较3组受试者性激素水平的差异。结果 与健康老年人和肝火上炎证患者相比，老年人高血压病肾气亏虚证患者存在性激素平衡紊乱的情况：老年男性高血压病肾气亏虚证患者存在雄激素（T）水平下降（P＜0.05）、T/E2比值显著下降（P＜0.01）现象；老年女性高血压病肾气亏虚证患者存在雌激素（E2）水平下降（P＜0.05）、T/E2比值上升（P＜0.05）的现象。结论 性激素平衡失调是老年人高血压病肾气亏虚证发生的危险因素，可作为其病因的推测及客观化证型诊断的参考。 　　关键词: 老年人高血压病；性激素；肾气亏虚证；证型诊断客观化 　　中图分类号：R544.1 R255.3文献标识码：A doi:10.3969/j.issn.1672 1349.2014.05.015 文章编号：1672 　　1349（2014）05 0546 02 　　 　　 　　Effect of Serum Sex Hormone Level on Diagnosis of Elderly Hypertension Disease with Kidney Qi Deficiency 　　Jing Ting,Ji Wenyan,lu Yinghong,et al//Qingdao Haici Medical Group Hospital (Qingdao 266033) 　　 　　Abstract:Objective To explore the relationship between sex hormone balance disorders and the elderly hypertension disease kidney with qi deficiency syndrome.Methods There were 40 elderly patient with hypertension in kidney deficiency syndrome group (male 20,female 20),40 elderly patients with hypertension in inflammation syndrome group (male 20,female 20),and 40 subjects as normal controls.Sex hormones of all patients were collected and compared by ria analysis.Results The level of androgen T (P0.05)and T/E2 ratio (P0.01) were significantly decreased in elderly male patients with hypertension and kidney deficiency syndrome.The estrogen E2 level was reduced (P0.05) and T/E2 ratio rose (P0.05) in female patients with hypertension and kidney qi deficiency syndrome.Conclusion Sex hormone level disorder was risk factors in elderly hypertension with kidney qi deficiency syndrome. 　　Key words:elderly hypertension;sex hormones;kidney qi deficiency syndrome 　　 　　老年人高血压病（EH）是老年人最常见的心血管疾病之一，因其患病率高、控制率低、并发症多、严重影响老年人的生存质量。性激素水平紊乱与原发性高血压的发生发展有一定的相关性，并且在老年人高血压病患者中表现尤为明显。但性激素平衡紊乱与老年人高血压病肾气亏虚证发病的相关性，以及老年人高血压病肾气亏虚证证型诊断的客观化有待进一步研究。本研究根据高血压病发病机制的现代研究，结合肾藏精、主生殖的中医理论，探讨性激素水平与老年人高血压病肾气亏虚证发病的相关性，并为老年人高血压病肾