重组人p53腺病毒联合放疗治疗鼻咽癌的临床分析-clinical analysis of recombinant human p53 adenovirus combined with radiotherapy for nasopharyngeal carcinoma.docx

安徽医科大学硕士学位论文 安徽医科大学硕士学位论文 PAGE PAGE 5 neck conventional radiotherapy continued 5 days a week and 2Gy a day and totally 6 weeks. Three days before the treatment, a week after the treatment and also a month after the treatment, the two groups were given blood routine, urine routine, hepatic function, renal function and electrocardiogram to check separately. Three days before the treatment and also a month after the treatment, both the groups were given the nasopharynx CT inspection separately. The pharynx nasalis dosage of two groups was 70 Gy/35 times, dosage of lymph nodes in cervical part was 60 Gy/30 times. Results: 1. Two groups were both given the nasopharynx CT inspection, a month after the treatmnet, the tumor body of the control group diden’t shrink obviously, compared to before treatment. As for the treatment group, a month after the treatment, the tumor body of the control group shrank obviously, compared to before treatment. By self-comparison, the tumor body shrank obviously before and after the treatment and the difference had statistics meaning (P0.05). As for the treatment group, the relative index of blood routine, routine urine test, hepatic function and renal function before and after treatment had no statistics meaning and there was no obvious abnormity. There was no other side effects except the self-limited fever. 6 difference of emotion condition had statistics meaning between treatment group and control group(P0.05). the others had no statistics meaning in basical conditon（P＞ 0.05）. Conclusion: 1. The unite radiotherapy of rAd-p53 to treat nasopharyngeal carcinoma is quite effective. 2.It is safe to treat nasopharyngeal carcinoma by unite radiotherapy of rAd-p53 and the patients who have side effects can tolerate. Keywords: P53 gene; Nasopharyngeal carcinoma; Radiotherapy 1 1 中英文缩略词表 英文缩写 英文全称 中文名称 Kb kilo base pair 千碱基对 mRNA messenger ribonucleic acid 信使核糖核酸 TACE transcatheter hepatic arterial chemoembolization 经皮肝动脉栓塞化疗术 VP virus particle