慢性肾功能不全患者二尖瓣瓣环位移值与肾小球滤过率关系分析.docVIP

慢性肾功能不全患者二尖瓣瓣环位移值与肾小球滤过率关系分析 　　[摘要] 目的 探讨慢性肾功能不全（CKD）患者二尖瓣瓣环位移（TMAD）值与肾小球滤过率（GFR）的关系。 方法 选取本院2014年12月～2015年7月收治的118例慢性肾功能不全并且经常规二维双平面Simpson法测量左室收缩功能（LVEF）≥50%的患者作为病例组，选取2015年2～4月的30例体检正常者作为对照组。病例组根据GFR水平从高到低分成4组。采用二维斑点追踪显像技术（STI）测量TMAD值。比较各组的TMAD值，分析GFR与TMAD值间的关系。 结果 4个病例组的TMADmid值显著低于对照组，差异有统计学意义（P0.05）。4个病例组间的TMADmid值比较，差异有统计学意义（P0.05）。TMADmid值随GFR的减低呈下降趋势。 结论 TMAD技术能够早期、准确地评价慢性肾功能不全患者GFR与左室收缩功能的关系，是一种简单、可行的检查左室收缩功能的新方法。 　　[关键词] 二尖瓣瓣环位移；左室收缩功能；慢性肾功能不全；斑点追踪成像 　　[中图分类号] R692.9 [文献标识码] A [文章编号] 1674-4721（2016）03（a）-0083-04 　　[Abstract] Objective To explore the relationship of tissue motion mitral annular displacement （TMAD） value and glomerular filtration rate （GFR） in patient with chronic renal insufficiency （CKD）. Methods 118 patients who were definitely diagnosed as CKD and left ventricular systolic function （LVEF） ≥50% by conventional two-dimensional biplane Simpson method from December 2014 to July 2015 in our hospital were selected as the disease group，30 cases of normal physical examination from February 2015 to April were selected as the control group.In the disease group，the cases were divided into 4 groups according to the level of GFR from high to low.The TMAD value was measured by Speckle-tracking imaging （STI）.The TMAD value among each group was compared，and the relationship between GFR and TMAD value was analyzed. Results The TMADmid values among 4 groups was lower than that in the control group，with significant difference （P0.05）.There was significant difference in TMADmin value of 4 disease groups （P0.05）.The TMADmid value decreased with the decrease of GFR. Conclusion TMAD can evaluate the correlation between GFR in CKD patients and left ventricular systolic function at an early stage and accurately，which is a simple and feasible new method to examine left ventricular systolic function. 　　[Key words] Tissue motion mitral annular displacement；Left ventricular systolic function；Chronic kidney disease；Speckle tracking imaging 　　慢性肾功能不全是各种肾脏疾病进行性