急诊抢救重症哮喘并发呼吸衰竭临床研究.docVIP

急诊抢救重症哮喘并发呼吸衰竭临床研究 　　[摘要] 目的 研究分析急诊抢救重症哮喘并发呼吸衰竭的临床效果。方法 整群选取该院2013年1月―2016年1月收治的218例重症哮喘并发呼吸衰竭患者作为研究对象，均分为对照组和观察组，对照组患者采用常规治疗，对另外109例观察组患者则在此基础上结合机械通气辅助治疗，并对两组的治疗效果等进行对比分析。结果 经统计分析，相比于治疗前，两组患者治疗后4 h的呼吸频率（RR）、PaCO2、PaO2、心律（HR）均有明显改善（P0.05），且相比于对照组，观察组的改善更为显著（P0.05），在两组长期使用茶碱类药物比例、间断应用吸入β2激动剂比例及规律使用皮质类激素比例、病死率的对比方面，观察组病死率（0%）明显低于对照组（6.4%）。结论 经该院研究得出，在对重症哮喘并发呼吸衰竭患者的急诊抢救方面，常规治疗联合机械通气辅助治疗的疗效较好，可以降低病死率，缓解哮喘发作，从而最大限度地抢救患者生命，应当推广使用。 　　[关键词] 重症哮喘；呼吸衰竭；急诊抢救；呼吸频率 　　[中图分类号] R562 [文献标识码] A [文章编号] 1674-0742（2016）05（a）-0079-03 　　[Abstract] Objective To research and analyze the clinical effect of emergency treatment for severe asthma combined with failure of respiration. Methods 218 cases of patients with severe asthma combined with failure of respiration admitted and treated in our hospital from January 2013 to January 2016 were selected as the research objects and divided into two groups with 109 cases in each， the control group adopted conventional treatment， the observation group adopted mechanical ventilation therapy combined with conventional treatment， and the treatment effects of the two groups were compared and analyzed. Results After statistical analysis， the respiratory rate， PaCO2， PaO2， heart rhythm at 4h after treatment were obviously improved compared with those before treatment， P0.05， and the improvement of the respiratory rate， PaCO2， PaO2， heart rhythm in the observation group was more obvious compared with that in the control group， P0.05， the case fatality rate after the long-term use of theophylline drugs， intermittent application of inhaled β2 agonists and regular use of cortical hormones in the observation group was obviously lower than that in the control group， （0% vs 6.4%）. Conclusion The research shows that the curative effect of mechanical ventilation therapy combined with conventional treatment for patients with severe asthma combined with failure of respiration is better， which can reduce the case fatality rate and relieve the asthmatic attack th