周期性动态力学载荷对抗骨质疏松的分析-analysis of periodic dynamic mechanical load to combat osteoporosis.docxVIP

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周期性动态力学载荷对抗骨质疏松的分析-analysis of periodic dynamic mechanical load to combat osteoporosis.docx

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周期性动态力学载荷对抗骨质疏松的分析-analysis of periodic dynamic mechanical load to combat osteoporosis

目录中文摘要······························································································· I ABSTRACT ······················································································· III 第 1 章绪论 1 1. 研究背景与现状··········································································· 1 1.1 骨的塑建、重建及其宏观力学调控机制 ········································ 1 1.2 力学刺激的传递与细胞响应························································ 2 1.3 骨质疏松模型的建立方法与评价指标············································ 3 1.4 动态力学载荷诱导的骨重建研究·················································· 5 2. 研究目的与意义··········································································· 7 2.1 研究目的 ················································································ 7 2.2 研究意义 ················································································ 7 3. 研究内容与方法··········································································· 7 3.1 小鼠骨质疏松模型的建立与验证·················································· 7 3.2 周期性动态力学加载条件的确定·················································· 7 3.3 周期性动态力学载荷对抗骨质疏松的研究 ····································· 7 4. 研究的技术路线··········································································· 8 参考文献 ······················································································· 8 第 2 章小鼠去势骨质疏松模型的建立与验证 ············································ 15 1. 引言 ························································································· 15 2. 材料与方法················································································ 15 2.1 实验动物 ··············································································· 15 2.2 主要试剂 ··············································································· 15 2.3 主要仪器 ··············································································· 15 2.4 实验方法 ··············································································· 15 3. 实验结果 ··············