中药淫羊藿苷预防人工髋关节无菌性松动实验分析-experimental analysis of icariin in preventing aseptic loosening of artificial hip joint.docx

中药淫羊藿苷预防人工髋关节无菌性松动实验研究 stimulation of polyethylene particles resulting prosthesis loosening of the animal model; of artificial hip replacement prosthesis after around the pathological changes and the application of icariin of wear particles from osteolysis. Method: 1, the establishment of osteoclasts in vitro system, osteoclast bone, and polyethylene particles icariin common culture, and the establishment of the control group. Observation of bone resorption lacunae in the number and size. 2, wear particles induced prosthetic loosening of the experimental animal model study. 3, icariin right hip aseptic loosening effects. Results: 1, polyethylene particles can significantly enhance osteoclastic bone resorption, and icariin could significantly inhibit particle-mediated osteoclast resorption. 2, measured bone mineral density in the experimental group under simulated rabbit femoral head prosthesis around the gap compared with the control group, also significantly lower bone mineral density values, the simulation of the experimental group of rabbit femoral head prosthesis osteolysis around the phenomenon, near the phantom simulation bone density than the control group decreased. 3, BMD Group A scan revealed that the experimental group simulated rabbit femoral head prosthesis around vague, and the distance between the bone tissue similar to zero, the higher value of bone mineral density; Group B and Group C simulation rabbit femoral head prosthesis around clear, and the gap between the bone tissue in the control group, bone mineral density was significantly lower. Gross observation and under, B, C next to that simulated phantom bone tissue necrosis, bone lacunae emptiness, bone fuzzy texture, not just the edge the whole, the surrounding fibrous tissue hyperplasia. Group A simulation phantom around the new bone 6 成都中医药大学 成都中医药大学 2005 级博士学位论文 formation. B and C of the tunnel